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Cat. No.: HY-186265

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SD-24

SD-24 is a selective antagonist targeting CCR2 with a K_i of 1 nM, and exhibits significantly reduced binding affinity to CXCR1 and CCR6. SD-24 is applicable for inflammation and immune-related research.

For research use only. We do not sell to patients.

CAS No.: 1237502-86-1
Formula: C₁₉H₁₂Cl₃NO₅S
Molecular Weight:472.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SD-24 Chemical Structure

CAS No.: 1237502-86-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

CCR2

1 nM (Ki)

All CCR Isoforms :

In Vitro

SD-24 (compound 15) (10 μM) shows no significant binding to the IABS of CXCR1_Nluc and CCR6_Nluc in HEK293T cell membranes at a concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1237502-86-1
Molecular Weight 472.73
Formula C₁₉H₁₂Cl₃NO₅S
SMILES

O=C(O)C1=CC=CC=C1OC2=C(NS(=O)(C3=CC(Cl)=C(Cl)C=C3)=O)C=C(Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huber ME, et al. Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1. ChemMedChem. 2024 Oct 16;19(20):e202400284. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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SD-24

All CCR Isoforms