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Etoposide phosphate

(Synonyms: BMY-40481)
180 Cited Publications
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Based on 180 publication(s) in Google Scholar

Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

For research use only. We do not sell to patients.

  • Purity: 99.44%
  • CAS No.: 117091-64-2
  • Formula: C29H33O16P
  • Molecular Weight:668.54
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Etoposide phosphate Chemical Structure
    Etoposide phosphate Chemical Structure
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
  • Experimental Validation Results for Etoposide phosphate
CAS No.: 117091-64-2
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  • Etoposide phosphate Chemical Structure
    Etoposide phosphate Chemical Structure
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    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Mar 7;134(10):e172716. [Abstract]

    Customer Validation
     The given cell lines were treated with 250 nM osimertinib (Osim), 1.25 μM Etoposide (VP-16), 125 nM Doxorubicin (DXR), 5 nM Paclitaxel, 10 μM Cisplatin, 25 μM Carboplatin, 25 nM Gemcitabine, 20 nM 5-Fluorouracil (5-FU), 25 μM Cyclophosphamide, 25 μM Capecitabine, or 10 nM Vincristine alone or in combination for 3 days. Cell numbers were then measured using the SRB assay.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 Nov 8;31(11):1820-1836.e10. [Abstract]

    Customer Validation
     Immunoblot and immunoprecipitation of lysates of HEK293T cells transfected with plasmids encoding Flag-UreC and exposed to etoposide (100 μg/ml) for 4 h.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Mar;42(13):967-979. [Abstract]

    Customer Validation
     Etoposide (VP16; 5 mg/kg; s.c.; every two days for 8 days) strongly suppresses tumor growth in mice.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: J Pharm Pharmacol. 2023 Apr 7;75(4):523-532. [Abstract]

    Customer Validation
     Irinotecan (CPT11; 20 μM; 48 h) or Etoposide (VP16; 20 μM; 48 h) induces MDA-MB-231 cells cycle arrest significantly.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     Cell sensitivity to Etoposide (ETO). Cancer cells are treated with etoposide at gradient concentrations for 48 hr.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     BCL6 mRNA expression in Etoposide (ETO)-resistant and -sensitive cells. Cells are treated with Etoposide at their respective 1/2 IC50s for 24 hr.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     Etoposide induced BCL6 protein expression in a time-dependent manner. ETO-resistant or -sensitive cells are treated with etoposide at their respective 1/4 IC50s for 2, 4, or 6 days.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     STAT1 protein and its phosphorylation levels by immunoblotting analysis. Etoposide (ETO)-resistant and -sensitive cells are treated with Etoposide at their respective 1/2 IC50s for indicated time points.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Elife. 2022 May 3;11:e69255. [Abstract]

    Customer Validation
     Etoposide activated mTOR signaling components in Etoposide-resistant Capan-2 and PANC28 cells. Cells were treated with etoposide at their respective 1/2 IC50s for 6 or 12 hr. A long-term treatment with Etoposide activated mTOR signaling components in ETO-resistant cells. Capan-2 and PANC28 cells are treated with 10 μM Etoposide for 2 or 4 days.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Jan;13(1):47-64. [Abstract]

    Customer Validation
     FISH of telomeres on metaphase spreads to detect chromosome end-to-end fusions in 6 kb-HeLa treated with VP-16. Control (Scr) or cGAS-depleted cells (gcGAS-1, gcGAS-2) are either harvested immediately following treatment (VP-16, 2 μM, 1 h) or released for 4 h (Release 4 h) during mitosis.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Mar 12;12(3):265. [Abstract]

    Customer Validation
     Inhibition of PRDX1 increased the sensitivity of HCT116 cells to Etoposide-induced apoptosis: HCT116 cells infected with lentivirus expressing the indicated shRNAs were treated with 50 μM Etoposide for 0-6 h.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Hepatology. 2020 May;71(5):1660-1677. [Abstract]

    Customer Validation
     Exposure to Etoposide (Eto), another DNA-damaging agent, induces PDIA3P1 expression, suggesting that PDIA3P1 may be up-regulated by DNA-damaging agents.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Sep 28;7(21):2001364. [Abstract]

    Customer Validation
     Lnc‐Ip53 attenuated the DNA damage- and oxidation stress-induced p53 acetylation at K382. Cells are incubated with 50 µM Etoposide (Eto) for 5 h.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2020 Sep 28;7(21):2001364. [Abstract]

    Customer Validation
     Lnc‐Ip53 attenuated the DNA damage‐ and oxidation stress‐triggered increase of CDKN1A and PUMA. Cells are incubated with 50 µM Etoposide (Eto) for 6 h.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]

    Customer Validation
     Fibroblasts and HT-1080 cells are treated with 20 µM Etoposide or DMSO (vehicle group) for 2, 4, 8, 16, 24 and 36 h.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]

    Customer Validation
     When cells are treated with 20 µM Etoposide or DMSO (vehicle group) for 4 h, western blots (WB) shows elevated expression of γH2AX, a marker of double-strand breaks (DSBs), in the Etoposide group.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Jul 25;10(21):9477-9494. [Abstract]

    Customer Validation
     When cells are treated with 20 µM Etoposide, an obvious increased green focus of RAD51 is observed in the treated fibroblasts using immunofluorescence (IF) staining.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2020 Nov 6;12(11):e12525. [Abstract]

    Customer Validation
     Immunoblot of PARP1 cleavage of PeTa cells after 6 days of indicated treatment. Etoposide (10 μM; for 24 h) serves as positive control for apoptosis, and H3 serves as loading control.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Aging Cell. 2020 Jul;19(7):e13171. [Abstract]

    Customer Validation
     RPE p16‐mCherry cells were treated with DMSO, Etoposide (20 μM), H2O2 (200 μM), or serum starved for 24 hr.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Leuk Lymphoma. 2018 Jan;59(1):162-170. [Abstract]

    Customer Validation
     WT1 and caspase-3 protein levels are detected in two primary AML blasts treated with 100 μM Eto for 24 h.

  • 1/16

    Etoposide phosphate purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Nov 1:408:43-54. [Abstract]

    Customer Validation
     Western blot analysis of p-p70S6k, p70S6k, p-AKT and AKT after 6 h of treatment with 20 μM RAD001. Levels of p-p70S6k and p-AKT are quantified by densitometric analysis and a corresponding histogram is constructed as relative to p70S6k or AKT and α-tubulin. The lower panel shows a representative Western blot.

  • Etoposide phosphate