iBFAR2
Based on 1 Customer Validation
iBFAR2, a BFAR inhibitor, restores the CD8+ TRM cell subset against solid tumors. iBFAR2 promotes JAK2-STAT1 association and STAT1 phosphorylation.
For research use only. We do not sell to patients.
- Purity: 97.24%
- CAS No.: 353484-02-3
- Formula: C19H15F3N2O2
- Molecular Weight:360.33
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
iBFAR2 abolishes USP39 ubiquitination, inhibits the JAK2-USP39 interaction and thus suppresses JAK2 deubiquitination, thereby promoting JAK2-STAT1 association and STAT1 phosphorylation in mouse primary CD8+ T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 353484-02-3
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Appearance Solid
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Molecular Weight 360.33
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Formula C19H15F3N2O2
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Color Light yellow to yellow
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SMILES
FC(F)(F)C1=CC=CC2=C1NC(C3=CC=C([N+]([O-])=O)C=C3)C4C2C=CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)