製品番号: HY-W016183

2,2'-Biphenol

(別名: o,o'-Biphenol)

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2,2'-Biphenol (o,o'-Biphenol) is an anti-inflammatory agent and the major non-protein-bound phenolic metabolite activated by rat bone marrow homogenate and hydrogen peroxide. 2,2'-Biphenol inhibits lipopolysaccharide (LPS) (HY-D1056)-induced COX-2 mRNA and protein expression. 2,2'-Biphenol suppresses the binding of AP-1 and NF-κB to their respective consensus sequences. 2,2'-Biphenol is applicable to research related to inflammation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1806-29-7
分子式: C₁₂H₁₀O₂
分子量:186.21

保管条件:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

2,2'-Biphenol 構造式

CAS 番号: 1806-29-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

COX-2

COX アイソフォーム固有の製品をすべて表示 :

AP-1 アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	57 μg/mL Compound: 3	Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
HepG2	IC₅₀	>200 μM Compound: 5	Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined	[PMID: 15582432]
HT-29	IC₅₀	2.5 μg/mL Compound: 3	Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
MCF7	IC₅₀	60 μg/mL Compound: 3	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]

体外実験

The CC₅₀ value of 2,2'-Biphenol (24 h) against RAW 264.7 cells is 0.55 mM^[1].
2,2'-Biphenol (1-100 μM; 3.5 h) significantly inhibits LPS-induced COX-2 mRNA expression in RAW 264.7 cells^[1].
2,2'-Biphenol (1-10 μM; 6.5 h) potently inhibits LPS-induced COX-2 protein expression in RAW 264.7 cells^[1].
2,2'-Biphenol (1-10 μM; 1.5 h) inhibits LPS-induced DNA-binding activities of AP-1 and NF-κB in RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

murine macrophage-like RAW 264.7 cells
Concentration:

1, 10 and 100 μM
Incubation Time:

30 min pretreatment, followed by 6 h LPS stimulation
Result:

Significantly inhibited LPS-stimulated COX-2 protein production.
Inhibited LPS-induced DNA-binding activities of AP-1 and NF-κB.

化学情報

CAS 番号 1806-29-7
性状 Solid
分子量 186.21
分子式 C₁₂H₁₀O₂
Color White to off-white
SMILES

OC1=C(C2=CC=CC=C2O)C=CC=C1
別名

o,o'-Biphenol
Structure Classification
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Murakami Y, et al. Antioxidant and cyclooxygenase-2-inhibiting activity of 4,4'-biphenol, 2,2'-biphenol and phenol. Anticancer Res. 2009 Jun;29(6):2403-10.
[Content Brief]

[2]. Subrahmanyam VV, et al. Peroxidase/hydrogen peroxide--or bone marrow homogenate/hydrogen peroxide--mediated activation of phenol and binding to protein. Xenobiotica. 1990;20(12):1369-1378. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2,2'-Biphenol

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Phenols Library

Pyroptosis Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Plant-Sourced Natural Product Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Lactylation Compound Library

COX アイソフォーム固有の製品をすべて表示

AP-1 アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

2,2'-Biphenol 関連分類

HY-W016183 関連分類