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製品番号: HY-144830

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6BrCaQ

6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates.

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CAS 番号: 954416-67-2
分子式: C₁₈H₁₅BrN₂O₃
分子量:387.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

6BrCaQ 構造式

CAS 番号: 954416-67-2

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Use of MCE Products

Fluorescent Dye

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生物活性

製品説明

6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates^[1].

HSP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	8 μM Compound: 6BrCaQ	Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
HT-29	IC₅₀	20 μM Compound: 6BrCaQ	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34952432]
IGROV-1	IC₅₀	5 μM Compound: 6BrCaQ	Antiproliferative activity against human IGROV1 cells assessed as inhibition of cell proliferation Antiproliferative activity against human IGROV1 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
Ishikawa	IC₅₀	2 μM Compound: 6BrCaQ	Antiproliferative activity against human Ishikawa cells assessed as inhibition of cell proliferation Antiproliferative activity against human Ishikawa cells assessed as inhibition of cell proliferation	[PMID: 24992077]
LP-1	GI₅₀	6.2 μM Compound: 6BrCaQ	Growth inhibition of human LP-1 cells after 72 hrs by MTS assay Growth inhibition of human LP-1 cells after 72 hrs by MTS assay	[PMID: 24992077]
MCF7	GI₅₀	7 μM Compound: 6BrCaQ	Growth inhibition of ER-positive human MCF7 cells after 72 hrs by MTT assay Growth inhibition of ER-positive human MCF7 cells after 72 hrs by MTT assay	[PMID: 24992077]
MCF7	IC₅₀	7 μM Compound: 6BrCaQ	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
MCF7	IC₅₀	7 μM Compound: 6BrCaQ	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 34952432]
MDA-MB-231	GI₅₀	0.06 μM Compound: 6BrCaQ	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay	[PMID: 34952432]
MDA-MB-231	GI₅₀	2 μM Compound: 6BrCaQ	Growth inhibition of ER-negative human MDA-MB-231 cells after 72 hrs by MTT assay Growth inhibition of ER-negative human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 24992077]
MDA-MB-231	IC₅₀	2 μM Compound: 6BrCaQ	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation	[PMID: 24992077]
PC-3	GI₅₀	10 μM Compound: 6BrCaQ	Growth inhibition of human PC3 cells after 72 hrs by MTS assay Growth inhibition of human PC3 cells after 72 hrs by MTS assay	[PMID: 24992077]
RPMI-8226	GI₅₀	5 μM Compound: 6BrCaQ	Growth inhibition of human RPMI8226 cells after 72 hrs by MTS assay Growth inhibition of human RPMI8226 cells after 72 hrs by MTS assay	[PMID: 24992077]

化学情報

CAS 番号 954416-67-2
分子量 387.23
分子式 C₁₈H₁₅BrN₂O₃
SMILES

COC1=CC=C(C=C1)C(NC2=CC3=CC(Br)=CC=C3N(C2=O)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mathieu C, et, al. Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1. Eur J Med Chem. 2022 Feb 5;229:114052. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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参考文献

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6BrCaQ

HSP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

6BrCaQ 関連分類

HY-144830 関連分類