カルベンダジム
Based on 6 publication(s) in Google Scholar
Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.54%
- CAS 番号: 10605-21-7
- 分子式: C9H9N3O2
- 分子量:191.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Anti-Cancer Compound Library
HY-L025
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Clinical Compound Library
HY-L026
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Antifungal Compound Library
HY-L048
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Anti-Blood Cancer Compound Library
HY-L079
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Antiparasitic Compound library
HY-L082
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Human Metabolite Library
HY-L123
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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Pesticide Compound Library
HY-L183
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Environmental Pollutant Compound Library
HY-L247
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MCE Kinase Hinge Binder Fragment Library
HY-L907
MedChemExpress（MCE）の使用を引用している文献 Carbendazim
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生物活性
Carbendazim (4-60 μM; 24 hours) has no effects on viability of HeLa cells in a CCK-8 assay[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old male ICR mice[2]
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Dosage:100 and 500 mg/kg
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Administration:Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days
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Result:Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis.Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice.Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 10605-21-7
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性状 Solid
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分子量 191.19
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分子式 C9H9N3O2
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Color White to off-white
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SMILES
O=C(OC)NC1=NC2=CC=CC=C2N1
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別名
Carbendazim
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
Sestrin2 improves intestinal ischemia-reperfusion injury through the TFEB-mediated autophagy/lysosomal pathway. [Abstract]2025 Jun 24:238:344-359. PMID: 40570983 -
Toxics
Antagonistic Effects of Enrofloxacin on Carbendazim-Induced Developmental Toxicity in Zebrafish Embryos. [Abstract]2021 Dec 10;9(12):349. PMID: 34941783 -
Chemosphere
Antagonistic effects and mechanisms of carbendazim and chlorpyrifos on the neurobehavior of larval zebrafish. [Abstract]2022 Apr:293:133522. PMID: 34995633 -
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Chemosphere
Individual and synergistic toxic effects of carbendazim and chlorpyrifos on zebrafish embryonic development. [Abstract]2021 Oct:280:130769. PMID: 34162088
溶剤 & 溶解度
DMSO : 6.8 mg/mL (35.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (276 KB)
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SDS (761 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2304 mL | 26.1520 mL | 52.3040 mL | 130.7600 mL |
| 5 mM | 1.0461 mL | 5.2304 mL | 10.4608 mL | 26.1520 mL | |
| 10 mM | 0.5230 mL | 2.6152 mL | 5.2304 mL | 13.0760 mL | |
| 15 mM | 0.3487 mL | 1.7435 mL | 3.4869 mL | 8.7173 mL | |
| 20 mM | 0.2615 mL | 1.3076 mL | 2.6152 mL | 6.5380 mL | |
| 25 mM | 0.2092 mL | 1.0461 mL | 2.0922 mL | 5.2304 mL | |
| 30 mM | 0.1743 mL | 0.8717 mL | 1.7435 mL | 4.3587 mL |
Carbendazim 関連分類
HY-13582 関連分類
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