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マトリン

(別名: Matrine; Matridin-15-one; Vegard; α-Matrine)
19 Cited Publications
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Based on 19 publication(s) in Google Scholar

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).

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  • 純度: 98.0%
  • CAS 番号: 519-02-8
  • 分子式: C15H24N2O
  • 分子量:248.36
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Matrine Chemical Structure
    Matrine 構造式
  • Experimental Validation Results for Matrine
  • Experimental Validation Results for Matrine
  • Experimental Validation Results for Matrine
  • Experimental Validation Results for Matrine
  • Experimental Validation Results for Matrine
  • Experimental Validation Results for Matrine
CAS 番号: 519-02-8
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  • Matrine Chemical Structure
    Matrine Chemical Structure
    1/16
  • 1/16

    Matrine purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Jun 26:350:120054. [Abstract]

    Customer Validation
     Immunofluorescence imaging of F-actin using phalloidin staining in 4T1 and MDA-MB-231 cells treated with MT (50 μM, 24 h). Phalloidin was diluted in PBS containing 5% bovine serum albumin and incubated at room temperature for 1 h in the dark.

  • 1/16

    Matrine purchased from MedChemExpress. Usage Cited in: Chin Med. 2022 Feb 18;17(1):23. [Abstract]

    Customer Validation
     Matrine (6.25, 12.5, 25, 50, 100, and 200 µM; 24 h) inhibited the growth of HSCs.

  • 1/16

    Matrine purchased from MedChemExpress. Usage Cited in: Chin Med. 2022 Feb 18;17(1):23. [Abstract]

    Customer Validation
     Matrine (50 µM, 24 h) inhibited the mRNA expression of α-SMA and collagen I in TGFβ1-activated HSC-T6 cells.

  • 1/16

    Matrine purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Aug:128:110327. [Abstract]

    Customer Validation
     Overexpression of miR-182-5p abolishes the Matrine-induced increase in caspase3 expression and decrease in Bcl-2 expression in vivo. Tumor sections are subjected to IHC staining using an antibody specific for caspase3 and Bcl-2.

  • 1/16

    Matrine purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2019 May;17(5):3775-3780. [Abstract]

    Customer Validation
     Matrine promotes the nuclear Foxo3a localization and inhibits the levels of cytoplasmic Foxo3a. RC‑4B/C cells are treated with increasing concentrations of matrine for 24 h. The levels of Foxo3 are determined by western blotting analysis. β‑tubulin is used as cytoplasmic marker and lamin B1 is used as nuclear marker in RC‑4B/C cells. The gray values of Foxo3a is shown in histogram in different concentrations of matrine‑treated pituitary cancer cells.

  • 1/16

    Matrine purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2019 May;17(5):3775-3780. [Abstract]

    Customer Validation
     Matrine increases the expression of pro‑apoptotic proteins in RC‑4B/C cells. RC‑4B/C cells are treated with 0.1, 0.5 and 2.5 mg/ml of matrine for 24 h and the expression of Bim, Bax and Bcl‑2 is determined by western blotting analysis. RC‑4B/C cells treated with 0.1% DMSO are used as negative controls. β‑actin is used as internal reference gene in pituitary cancer cells.

  • Matrine