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Oxaliplatin

(別名: オキサリプラチン)
226 Cited Publications
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Based on 226 publication(s) in Google Scholar

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research.

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  • 純度: 99.65%
  • CAS 番号: 61825-94-3
  • 分子式: C8H14N2O4Pt
  • 分子量:397.29
  • 保管条件:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Oxaliplatin Chemical Structure
    Oxaliplatin 構造式
  • Experimental Validation Results for Oxaliplatin
  • Experimental Validation Results for Oxaliplatin
  • Experimental Validation Results for Oxaliplatin
  • Experimental Validation Results for Oxaliplatin
  • Experimental Validation Results for Oxaliplatin
  • Experimental Validation Results for Oxaliplatin
CAS 番号: 61825-94-3
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  • Oxaliplatin Chemical Structure
    Oxaliplatin Chemical Structure
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    Oxaliplatin purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2024 Dec 3:78:101179. [Abstract]

    Customer Validation
     Oxaliplatin (100 nM-4 μM; 48 h) inhibits CEAhigh (AGS) and CEA-⁠/lo (xhGC1) gastric cancer cells, with IC50 values of 150 nM and 2.2 μM, respectively.

  • 1/16

    Oxaliplatin purchased from MedChemExpress. Usage Cited in: Nat Med. 2024 Mar;30(3):749-761. [Abstract]

    Customer Validation
     The relative cell viability of shCtl-, shNDUFB8-, and shCEMIP2-transfected cells was detected by XTT assay after paclitaxel plus gemcitabine treatment (A+G), single-agent 5-Fu (5-FU), and the FOLFIRINOX chemotherapy cocktail [FU+IRI+OXA: 5-FU+Irinotecan (SN-38) +Oxaliplatin (50 nM)] for 48h.

  • 1/16

    Oxaliplatin purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Jan;20(1):51-64. [Abstract]

    Customer Validation
     Comparison of drug (Epirubicin hydrochloride, EPI; Daunorubicin hydrochloride, DNR; Vinorelbine ditartrate, VNR; Oxaliplatin, OXA; Vincristine, VCR; Artemisinin, ART; Colchicine, COL) cytotoxicity to TC1 cells at the indicated doses and time points measured with CCK-8 assays. R.U. (Relative unit) was calculated from the average O.D. values in each condition as the indicator of cell viability (n = 3).

  • 1/16

    Oxaliplatin purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2021 Nov;161(5):1601-1614.e23. [Abstract]

    Customer Validation
     Bar graphs show the GI50 of 5-fluoruracil (48 h), irinotecan (48 h), gemcitabine (48 h), paclitaxel (48 h), and oxaliplatin (48 h) in PDAC cells in combination with bioactive hexapeptides (NTAIYY and PTTIYY) or controls (saline and NTAIYA).

  • 1/16

    Oxaliplatin purchased from MedChemExpress. Usage Cited in: Mol Oncol. 2020 Nov;14(11):2894-2919. [Abstract]

    Customer Validation
     FOLFOX was administered as 6 mg/kg Oxaliplatin two hours before administration of 90 mg/kg Leucovorin and 50 mg/kg 5-Fluorouracil at day 1 and a repeat of 5‐Fluorouracil dosing on day 2. Weight loss of ODC-, CTRL-, and FOLFOX-treated mice over time of mice with DLD1 tumors.

  • 1/16

    Oxaliplatin purchased from MedChemExpress. Usage Cited in: Nat Med. 2019 Sep;25(9):1428-1441. [Abstract]

    Customer Validation
     Quantification of CD3+IFN-γ+ T cells in lung lobes taken from urethane-induced primary lung cancer models (n = 5 mice for SD group, n = 6 mice for all the other groups). Three coronal sections containing five pulmonary lobes from each mouse near the maximal diameters are quantified. Each dot represents one view field. A representative result from two independent experiments is shown.

  • Oxaliplatin