パパイン
Based on 17 publication(s) in Google Scholar
Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9001-73-4
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Help & FAQs
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HY-Y0337
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HY-P1635
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Collagenase, Type IIZinc peptidase, Matrix metalloproteinases (MMPs) -
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Proteinase KSerine Protease -
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TrypsinSerine Protease -
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Trypsin (MS grade)Serine Protease -
HY-P1645A
Papain (1.5-10 units/mg)Papain -
HY-P1645B
Papain (lyophilized powder, ≥10 units/mg protein)Papain -
HY-E70005D
Collagenase IV, Clostridium histolyticaZinc peptidase, Matrix metalloproteinases (MMPs) -
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MedChemExpress（MCE）の使用を引用している文献 Papain
More- Bioact Mater. 2022 Jul 20:25:701-715. [Abstract]
- Nat Neurosci. 2023 Dec;26(12):2081-2089. [Abstract]
- Nat Commun. 2025 Mar 8;16(1):2333. [Abstract]
- Acta Pharm Sin B. 2026 Feb 13.
- Acta Pharm Sin B. 2023 Oct;13(10):4318-4336. [Abstract]
- Sci Adv. 2025 Aug;11(31):eadu4270. [Abstract]
- J Neuroinflammation. 2024 Oct 28;21(1):278. [Abstract]
- J Neuroinflammation. 2022 Jun 27;19(1):166. [Abstract]
- Mol Psychiatry. 2025 Sep 16. [Abstract]
- Cell Mol Neurobiol. 2022 May;42(4):1153-1166. [Abstract]
- Life Sci. 2020 Oct 1:258:118099. [Abstract]
- Int Immunopharmacol. 2026 Aug 1:182:116724. [Abstract]
- Behav Brain Res. 2019 Oct 17:372:111950. [Abstract]
- Biochem Biophys Res Commun. 2019 Nov 19;519(4):803-811. [Abstract]
- SSRN. 2026 Jun 8.
- bioRxiv. 2026 Feb 28.
- Research Square Preprint. 2024 Jan 24.
Cathepsin アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells enhances anti-D-mediated agglutination, while it slightly reduces anti-A-mediated agglutination of A Rh-negative red cells[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells increases their sensitivity to lymphocyte-mediated lysis in anti-D-mediated ADCC assays at low antibody concentrations and a 15:1 effector-to-target ratio[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive target red cells enables significant PBMC-mediated lysis in anti-D-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
Papain (5 U/mL; 15 min) pretreatment of A Rh-negative target red cells enables significant PBMC-mediated lysis in anti-A-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 20-25 g)[1]
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Dosage:10 IU
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Administration:Intratracheal instillatio; days 0 and 7
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Result:Increased viscoelastic/inhomogeneous pressure, static elastance, and viscoelastic component of elastance.
Increased polymorphonuclear (PMN) cell count, mean alveolar diameter, functional residual capacity (FRC) and decreased elastic fiber area.
Increased KC levels, MIP-2 levels, and IFN-γ levels.
Left TNF-α, IL-1β, and IL-6 levels unchanged relative to saline controls.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 9001-73-4
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性状 Solid
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Color White to off-white
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SMILES
[Papain]
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別名
Papain
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Structure Classification
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Initial Source
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輸送条件
Shipping with dry ice.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (17)
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Journal Impact Factor
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Most Recent
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Bioact Mater
A bioinspired and high-strengthed hydrogel for regeneration of perforated temporomandibular joint disc: Construction and pleiotropic immunomodulatory effects. [Abstract]2022 Jul 20:25:701-715. PMID: 37056268 -
Nat Neurosci
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage. [Abstract]2023 Dec;26(12):2081-2089. PMID: 37996529 -
Nat Commun
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis. [Abstract]2025 Mar 8;16(1):2333. PMID: 40057602 -
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Acta Pharm Sin B
An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing. [Abstract]2023 Oct;13(10):4318-4336. PMID: 37799395 -
Sci Adv
Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I. [Abstract]2025 Aug;11(31):eadu4270. PMID: 40749060 -
J Neuroinflammation
Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. [Abstract]2024 Oct 28;21(1):278. PMID: 39468551 -
J Neuroinflammation
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. [Abstract]2022 Jun 27;19(1):166. PMID: 35761401 -
Mol Psychiatry
Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling. [Abstract]2025 Sep 16. PMID: 40954280 -
Cell Mol Neurobiol
2022 May;42(4):1153-1166. PMID: 33201418 -
Life Sci
Astrocytes-induced neuronal inhibition contributes to depressive-like behaviors during chronic stress. [Abstract]2020 Oct 1:258:118099. PMID: 32682917 -
Int Immunopharmacol
VEGF-C silencing unlocks therapeutic synergy between MSCs and dexamethasone for osteoarthritis repair. [Abstract]2026 Aug 1:182:116724. PMID: 42096958 -
Behav Brain Res
Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours. [Abstract]2019 Oct 17:372:111950. PMID: 31103752 -
Biochem Biophys Res Commun
Hippocampal astrocyte dysfunction contributes to etomidate-induced long-lasting synaptic inhibition. [Abstract]2019 Nov 19;519(4):803-811. PMID: 31558319 -
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溶剤 & 溶解度
体外:
H2O : 12.5 mg/mL (Need ultrasonic)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Machado MN, et al. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. Front Physiol. 2018;9:121. Published 2018 Feb 20. [Content Brief]
[2]. Kumpel BM, et al. Comparison of lysis of bromelain and papain treated red cells in ADCC assays. Immunol Lett. 1992;31(3):237-240. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Papain 関連分類
HY-P1645 関連分類
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