パパイン
Based on 17 publication(s) in Google Scholar
Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9001-73-4
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Papain
More- Bioact Mater. 2022 Jul 20:25:701-715. [Abstract]
- Nat Neurosci. 2023 Dec;26(12):2081-2089. [Abstract]
- Nat Commun. 2025 Mar 8;16(1):2333. [Abstract]
- Acta Pharm Sin B. 2026 Feb 13.
- Acta Pharm Sin B. 2023 Oct;13(10):4318-4336. [Abstract]
- Sci Adv. 2025 Aug;11(31):eadu4270. [Abstract]
- J Neuroinflammation. 2024 Oct 28;21(1):278. [Abstract]
- J Neuroinflammation. 2022 Jun 27;19(1):166. [Abstract]
- Mol Psychiatry. 2025 Sep 16. [Abstract]
- Cell Mol Neurobiol. 2022 May;42(4):1153-1166. [Abstract]
- Life Sci. 2020 Oct 1;258:118099. [Abstract]
- Int Immunopharmacol. 2026 Aug 1:182:116724. [Abstract]
- Behav Brain Res. 2019 Oct 17:372:111950. [Abstract]
- Biochem Biophys Res Commun. 2019 Nov 19;519(4):803-811. [Abstract]
- SSRN. 2026 Jun 8.
- bioRxiv. 2026 Feb 28.
- Research Square Preprint. 2024 Jan 24.
Cathepsin アイソフォーム固有の製品をすべて表示
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生物活性
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells enhances anti-D-mediated agglutination, while it slightly reduces anti-A-mediated agglutination of A Rh-negative red cells[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive red cells increases their sensitivity to lymphocyte-mediated lysis in anti-D-mediated ADCC assays at low antibody concentrations and a 15:1 effector-to-target ratio[2].
Papain (5 U/mL; 15 min) pretreatment of O Rh-positive target red cells enables significant PBMC-mediated lysis in anti-D-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
Papain (5 U/mL; 15 min) pretreatment of A Rh-negative target red cells enables significant PBMC-mediated lysis in anti-A-mediated ADCC assays at a 1:3:3 effector-to-target-to-competitor ratio[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 20-25 g)[1]
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Dosage:10 IU
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Administration:Intratracheal instillatio; days 0 and 7
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Result:Increased viscoelastic/inhomogeneous pressure, static elastance, and viscoelastic component of elastance.
Increased polymorphonuclear (PMN) cell count, mean alveolar diameter, functional residual capacity (FRC) and decreased elastic fiber area.
Increased KC levels, MIP-2 levels, and IFN-γ levels.
Left TNF-α, IL-1β, and IL-6 levels unchanged relative to saline controls.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 9001-73-4
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性状 Solid
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Color White to off-white
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SMILES
[Papain]
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別名
Papain
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Structure Classification
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Initial Source
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輸送条件
Shipping with dry ice.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (17)
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Journal Impact Factor
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Most Recent
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Bioact Mater
A bioinspired and high-strengthed hydrogel for regeneration of perforated temporomandibular joint disc: Construction and pleiotropic immunomodulatory effects. [Abstract]2022 Jul 20:25:701-715. PMID: 37056268 -
Nat Neurosci
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage. [Abstract]2023 Dec;26(12):2081-2089. PMID: 37996529 -
Nat Commun
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis. [Abstract]2025 Mar 8;16(1):2333. PMID: 40057602 -
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Acta Pharm Sin B
An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing. [Abstract]2023 Oct;13(10):4318-4336. PMID: 37799395 -
Sci Adv
Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I. [Abstract]2025 Aug;11(31):eadu4270. PMID: 40749060 -
J Neuroinflammation
Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. [Abstract]2024 Oct 28;21(1):278. PMID: 39468551 -
J Neuroinflammation
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. [Abstract]2022 Jun 27;19(1):166. PMID: 35761401 -
Mol Psychiatry
Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling. [Abstract]2025 Sep 16. PMID: 40954280 -
Cell Mol Neurobiol
2022 May;42(4):1153-1166. PMID: 33201418 -
Life Sci
Astrocytes-induced neuronal inhibition contributes to depressive-like behaviors during chronic stress. [Abstract]2020 Oct 1;258:118099. PMID: 32682917 -
Int Immunopharmacol
VEGF-C silencing unlocks therapeutic synergy between MSCs and dexamethasone for osteoarthritis repair. [Abstract]2026 Aug 1:182:116724. PMID: 42096958 -
Behav Brain Res
Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours. [Abstract]2019 Oct 17:372:111950. PMID: 31103752 -
Biochem Biophys Res Commun
Hippocampal astrocyte dysfunction contributes to etomidate-induced long-lasting synaptic inhibition. [Abstract]2019 Nov 19;519(4):803-811. PMID: 31558319 -
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溶剤 & 溶解度
H2O : 12.5 mg/mL (Need ultrasonic)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Machado MN, et al. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. Front Physiol. 2018;9:121. Published 2018 Feb 20. [Content Brief]
[2]. Kumpel BM, et al. Comparison of lysis of bromelain and papain treated red cells in ADCC assays. Immunol Lett. 1992;31(3):237-240. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Papain 関連分類
HY-P1645 関連分類
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