製品番号: HY-12808

STF-118804

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.72%
CAS 番号: 894187-61-2
分子式: C₂₅H₂₃N₃O₄S
分子量:461.54

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

STF-118804 構造式

CAS 番号: 894187-61-2

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (3)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer^[1]^[2].

AMPK アイソフォーム固有の製品をすべて表示 :

mTOR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
B-ALL	EC₅₀	0.061 μM Compound: 1	Antiproliferative activity against mouse B-ALL BCR-ABL double knockout cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against mouse B-ALL BCR-ABL double knockout cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
B-ALL	EC₅₀	0.072 μM Compound: 1	Antiproliferative activity against mouse B-ALL cells expressing wild type BCR-ABL assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against mouse B-ALL cells expressing wild type BCR-ABL assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
BJ	EC₅₀	2.4938 μM Compound: 1	Antiproliferative activity against human BJ assessed as cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human BJ assessed as cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
K562	EC₅₀	4.6 μM Compound: 1	Antiproliferative activity against human K562 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human K562 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
KOPN-8	EC₅₀	1.23 μM Compound: 1	Antiproliferative activity against human KOPN8 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human KOPN8 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
MV4-11	EC₅₀	3.8 μM Compound: 1	Antiproliferative activity against human MV411 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human MV411 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
NALM-6	EC₅₀	0.026 μM Compound: 1	Antiproliferative activity against human NALM6 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human NALM6 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
SUP-B15	EC₅₀	1.1 μM Compound: 1	Antiproliferative activity against human SUP-B15 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human SUP-B15 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]
UoC-B1	EC₅₀	>54.98 μM Compound: 1	Antiproliferative activity against human UOCB1 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human UOCB1 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 30611980]

体外実験

STF-118804 (6.25-25 nM, 72 h) reduces viability and growth of different pancreatic ductal adenocarcinoma cells (PaTu8988t, Panc-1, Su86.86, Panc04.03)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PaTu8988t, Panc-1, Su86.86, Panc04.03
Concentration:

6.25, 12.5, 25 nM
Incubation Time:

72 h
Result:

Showed more sensitivity to Panc-1 and PaTu8988t cells.

体内実験

STF-118804 (25 mg/kg, i.p., 3 weeks) demonstrates antitumor activity in an orthotopic mouse model of PDAC (Panc-1)^[1].
STF-118804 (50 mg/kg, s.c., 20 days) improves survival in an orthotopic xenotransplant mouse model of high-risk acute lymphoblastic leukemia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice (gender not specified, age 4 - 6 weeks) inoculated with Panc-1 cells expressing GFP-luciferase to establish an orthotopic pancreatic cancer model^[1]
Dosage:

25 mg/kg
Administration:

Intraperitoneal injection (i.p.), 3 weeks
Result:

Reduced tumor growth as demonstrated by decreased luminescence, tumor weight and size.
Had no significant toxicity.

化学情報

CAS 番号 894187-61-2
性状 Solid
分子量 461.54
分子式 C₂₅H₂₃N₃O₄S
Color White to light yellow
SMILES

O=C(NCC1=CC=CN=C1)C2=CC=C(C3=NC(CS(=O)(C4=CC=C(C)C=C4)=O)=C(C)O3)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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PLoS Pathog

Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles. [Abstract]

2026 Apr 22;22(4):e1014165. PMID: 42018568
bioRxiv

2025 Oct 14.
Patent

US20180263995A1.

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (54.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1667 mL

10.8333 mL

21.6666 mL

5 mM

0.4333 mL

2.1667 mL

4.3333 mL

10 mM

0.2167 mL

1.0833 mL

2.1667 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Espindola-Netto JM, et al. Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer. Oncotarget. 2017 Jun 29;8(49):85054-85067. [Content Brief]

[2]. Matheny CJ, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20(11):1352-63. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1667 mL	10.8333 mL	21.6666 mL	54.1665 mL
	5 mM	0.4333 mL	2.1667 mL	4.3333 mL	10.8333 mL
	10 mM	0.2167 mL	1.0833 mL	2.1667 mL	5.4166 mL
	15 mM	0.1444 mL	0.7222 mL	1.4444 mL	3.6111 mL
	20 mM	0.1083 mL	0.5417 mL	1.0833 mL	2.7083 mL
	25 mM	0.0867 mL	0.4333 mL	0.8667 mL	2.1667 mL
	30 mM	0.0722 mL	0.3611 mL	0.7222 mL	1.8055 mL
	40 mM	0.0542 mL	0.2708 mL	0.5417 mL	1.3542 mL
	50 mM	0.0433 mL	0.2167 mL	0.4333 mL	1.0833 mL

Keywords

STF-118804

3 Cited Publications

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STF-118804

Epigenetics Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

PI3K/Akt/mTOR Compound Library

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MedChemExpress（MCE）の使用を引用している文献 STF-118804

AMPK アイソフォーム固有の製品をすべて表示

mTOR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (3)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

STF-118804 関連分類

HY-12808 関連分類