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Torin 1

133 Cited Publications
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Based on 133 publication(s) in Google Scholar

Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

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  • 純度: 99.28%
  • CAS 番号: 1222998-36-8
  • 分子式: C35H28F3N5O2
  • 分子量:607.62
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Torin 1 Chemical Structure
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Torin 1 Chemical Structure
    Torin 1 構造式
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
  • Experimental Validation Results for Torin 1
CAS 番号: 1222998-36-8
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  • Torin 1 Chemical Structure
    Torin 1 Chemical Structure
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  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604. [Abstract]

    Customer Validation
     AGS cells are pretreated with 25 and 50 nM PS-341 for 1 h, and then incubated with 500 nM Torin 1 for 24 h. After pretreatment with PPI for 24 h in pH 7.4 or pH 6.5 condition, Rapamycin (1 μM) or Torin 1 (500 nM) is added for another 24 h. The protein level of SQSTM1 is measured by western blot analysis.

  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 9;9(10):1032. [Abstract]

    Customer Validation
     Western blot showing the cell cycle and autophagy-related proteins after 48 h of treatment with 200 μM NSC 697855 (NTZ) and/or 500 nM Torin 1 or 30 mM Chloroquine (CQ).

  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: J Virol. 2018 Jul 31;92(16). pii: e00600-18. [Abstract]

    Customer Validation
     HEK293T cells treated with Torin 1 (250 nM, 6 h) are used as the positive control. The cells are harvested at 30 h posttransfection and the lysates are analyzed with immunoblotting using antibodies specific for the indicated proteins.

  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2018 Nov;43(11):2141-2154. [Abstract]

    Customer Validation
     Torin 1 (T) stimulation decreases the ratios of phospho-mTOR (Ser 2448)/ mTOR, phospho-S6K1 (Thr 389)/S6K1 and NGF/β-actin at all time points.

  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2018 Jun 15;367(2):186-195. [Abstract]

    Customer Validation
     Torin1 and Rapamycin downregulate phospho-mTOR (Ser 2448), phospho-S6K1 (Thr 389), phospho-4EBP1 (Thr 37/46), Bcl-2 and upregulate Bax, cleaved caspase-3 in vitro cultured RSC96 cells.

  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: Haematologica. 2017 Apr;102(4):755-764. [Abstract]

    Customer Validation
     Knocking out of 4EBPs induces resistance to TORKi treatment. Ramos is transduced with CRISPR-CAS9 vectors targeting both 4EPB1 and 4EBP2 and immunoblotted with the indicated antibodies. 48 h after treatment with AZD8055 or Torin1, 4EBP1/2 double knock-out (Ramos-DKO) and control (Ramos-C) Ramos cells are immunoblotted with antibodies against MCL1 and BCL-XL

  • 1/16

    Torin 1 purchased from MedChemExpress. Usage Cited in: Mol Cell Biol. 2017 Jun 29;37(14). pii: e00075-17. [Abstract]

    Customer Validation
     L-glutamine-responsive TORC1 activation in vitro. An in vitro kinase assay using semi-intact cells is performed. The reaction is performed with or without the indicated amount of Rapamycin or Torin-1. FLAG-tagged Tor1 and Myc-tagged Kog1 are detected as loading controls. The bar graph refers to the mean ratio of phosphorylated/total 4EBP1, normalized to the values for the DMSO-treated and glutamine-unadded samples.

  • Torin 1