AC-93253
Based on 1 Customer Validation
AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 108527-83-9
- 分子式: C23H25IN2S
- 分子量:488.43
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
SIRT1 45.3 μM (IC50) |
SIRT2 6 μM (IC50) |
SIRT3 24.6 μM (IC50) |
体外実験
AC93253 can inhibit SIRT1, SIRT2 and SIRT3 with IC50 values of 45.3 μM, 6 μM and 24.6 μM, respectively[1].
AC-93253 (0, 2, 5, 10 μM; 16 h) significantly enhanced the acetylation of tubulin, p53, and histone H4[1].
AC-93253 exhibits selective cytotoxicity towards four tumor cell lines in a single agent with IC50 values ranging from 10 to 100 nM[1].
AC-93253 significantly triggered apoptosis [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:NCI-H460 cells, HeLa cells
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Concentration:0, 2, 5, 10 μM
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Incubation Time:16 h
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Result:Increased the acetylation levels of a-tubulin in a dose-dependent manner.
Increased the level of histone protein and p53.
化学情報
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CAS 番号 108527-83-9
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性状 Solid
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分子量 488.43
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分子式 C23H25IN2S
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Color Brown to dark brown
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SMILES
CC1(C)C2=C(C=CC=C2)N(C)/C1=C/C=C/C3=[N+](CC)C4=C(C=CC=C4)S3.[I-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AC-93253 関連分類
HY-118343 関連分類
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