ACBI3
Based on 1 Customer Validation
ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models.
(Pink: K-Ras WT ligand (HY-162960); Blue: VHL ligand (HY-401613); Black: linker (HY-169992)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
The ACBI3 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
- 純度: 99.47%
- CAS 番号: 2938169-76-5
- 分子式: C50H62N14O6S2
- 分子量:1019.25
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
ACBI3 (0.01-10000 nM, 5 days) exhibits antiproliferative activity in KRAS mutant versus KRASWT cell lines (geometric mean IC50 =478 nM versus 8.3 μM, respectively). ACBI3 exhibits high efflux in the Caco-2 assay in LS513 cells[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KRAS mutant xenograft mouse models[1]
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Dosage:2 mg/kg i.v. or 30 mg/kg s.c. or 30 mg/kg i.p.
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Administration:once a day for 3 days
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Result:Resulted in pronounced tumor regressions with a tumor growth inhibition of 127% in KRAS mutant xenograft mouse models.
化学情報
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CAS 番号 2938169-76-5
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性状 Solid
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分子量 1019.25
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分子式 C50H62N14O6S2
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Color White to yellow
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SMILES
NC(SC1=C2[C@](C3=NC(C4=NC(N5CCCN(CCCCOC(N=N6)=CN6[C@@H](C(C)C)C(N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C9=C(N=CS9)C)=O)C[C@@H](O)C7)=O)C[C@@H]5C)=NC=C4)=NO3)(C)CCC1)=C2C#N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 140 mg/mL (137.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9811 mL | 4.9056 mL | 9.8111 mL | 24.5278 mL |
| 5 mM | 0.1962 mL | 0.9811 mL | 1.9622 mL | 4.9056 mL | |
| 10 mM | 0.0981 mL | 0.4906 mL | 0.9811 mL | 2.4528 mL | |
| 15 mM | 0.0654 mL | 0.3270 mL | 0.6541 mL | 1.6352 mL | |
| 20 mM | 0.0491 mL | 0.2453 mL | 0.4906 mL | 1.2264 mL | |
| 25 mM | 0.0392 mL | 0.1962 mL | 0.3924 mL | 0.9811 mL | |
| 30 mM | 0.0327 mL | 0.1635 mL | 0.3270 mL | 0.8176 mL | |
| 40 mM | 0.0245 mL | 0.1226 mL | 0.2453 mL | 0.6132 mL | |
| 50 mM | 0.0196 mL | 0.0981 mL | 0.1962 mL | 0.4906 mL | |
| 60 mM | 0.0164 mL | 0.0818 mL | 0.1635 mL | 0.4088 mL | |
| 80 mM | 0.0123 mL | 0.0613 mL | 0.1226 mL | 0.3066 mL | |
| 100 mM | 0.0098 mL | 0.0491 mL | 0.0981 mL | 0.2453 mL |
ACBI3 関連分類
HY-157228 関連分類
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