Antimalarial agent 63

Antimalarial agent 63 (compound 1b) potently inhibits chloroquine-sensitive Plasmodium falciparum 3D7 strain with an IC₅₀ of 14 nM, has low cytotoxicity against HepG2 cells (CC₅₀ = 8 μM), and a high selectivity index of 571^[1].
Antimalarial agent 63 does not exhibit cross-resistance to multidrug-resistant Plasmodium falciparum strains K1, Dd2, and 3D7^R_MMV848, with resistance indexes below 5^[1].
Antimalarial agent 63 potently inhibits ex vivo growth of Plasmodium falciparum field isolates (IC₅₀ = 51 nM) and Plasmodium vivax field isolates (IC₅₀ = 31 nM) from the Brazilian Amazon^[1].
Antimalarial agent 63 (10 × IC₅₀; 3-72 h) acts as a fast-acting inhibitor of Plasmodium falciparum 3D7 strain, achieving maximal inhibitory activity within 6 to 12 h of incubation and causing parasite death within 24 h^[1].
Antimalarial agent 63 shows an antagonistic interaction with Proguanil (HY-B0806) against Plasmodium falciparum.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.