Antimalarial agent 64

Antimalarial agent 64 (Compound 2d) potently inhibits Chloroquine (HY-17589A)-sensitive Plasmodium falciparum 3D7 strain growth with an IC₅₀ of 20 nM, has a CC₅₀ of 6 μM against HepG2 cells, and a selectivity index of 300^[1].
Antimalarial agent 64 retains potent antiplasmodial activity against Plasmodium falciparum K1, Dd2, and 3D7^R_MMV848 multidrug-resistant strains but shows cross-resistance with atovaquone in the TM90C6B strain^[1].
Antimalarial agent 64 potently inhibits ex vivo growth of Plasmodium falciparum (IC₅₀ = 39 nM) and Plasmodium vivax (IC₅₀ = 21 nM) field isolates from the Brazilian Amazon^[1].
Antimalarial agent 64 potently inhibits ring and trophozoite stages of Plasmodium falciparum 3D7 strain, with reduced activity against schizonts^[1].
Antimalarial agent 64 (10 μM) selectively accumulates near the digestive vacuole of Plasmodium falciparum-infected erythrocytes, with no uptake in uninfected red blood cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.