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Atibuclimab

(別名: IC14)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury.

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  • 純度: ≥99.0%
  • CAS 番号: 2417175-94-9
  • 分子量:145.5 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Atibuclimab
  • Experimental Validation Results for Atibuclimab
  • Experimental Validation Results for Atibuclimab
  • Atibuclimab Chemical Structure
    Atibuclimab 構造式
CAS 番号: 2417175-94-9
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized CD14 Protein, Human (HEK293, His, HY-P7786) can bind Atibuclimab. The EC50 for this effect is 22.13 ng/mL.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD14 (red) with Atibuclimab (anti-CD14) (HY-P99008). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Atibuclimab Chemical Structure
    1/16
  • Atibuclimab
  • Immobilized CD14 Protein, Human (HEK293, His, HY-P7786) can bind Atibuclimab. The EC50 for this effect is 22.13 ng/mL.
  • Flow Cytometry analysis of Raji cells labelling CD14 (red) with Atibuclimab (anti-CD14) (HY-P99008). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).