Azure C
Based on 1 Customer Validation
Azure C (Monomethylthionine) acts as a tau oligomer inhibitor and Aβ42 oligomerization inhibitor. Azure C regulates hsp70 ATPase activity, thereby mediating the clearance of tau protein. Azure C reduces the levels of toxic tau oligomers by promoting the formation of non-toxic tau aggregates, rescues neuroblastoma cells from tau oligomer-induced toxicity, and binds to and inhibits Aβ42 oligomerization. Azure C is generated via continuous oxidation of methylene blue or azure B through a horseradish peroxidase-mediated reaction. Azure C can be used in research related to tauopathies, including Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 65.15%
- CAS 番号: 531-57-7
- 分子式: C13H12ClN3S
- 分子量:277.78
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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HSP70 |
Azure C (0.05-10 μM; 16 h) reduces levels of purified preformed tau oligomers in a concentration-dependent manner, with a significant reduction observed at 5 μM[1].
Azure C (2.5-10 μM; 16 h) significantly reduces levels of purified preformed tau oligomers, without altering total tau levels[1].
Azure C (5 μM; 16 h preincubation with preformed tau oligomers) reduces the oligomers' toxicity to SH-SY5Y human neuroblastoma cells[1].
Azure C (5 μM; 16 h) reduces levels of toxic tau oligomers from crude tau oligomeric preparations and decreases their hydrophobicity, without disassembling oligomers into monomeric tau[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y human neuroblastoma cells
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Concentration:5 μM (preincubated with tau oligomers)
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Incubation Time:16 h (preincubation with tau oligomers); 24 h (cell treatment)
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Result:Resulted in significantly higher cell viability compared to treatment with tau oligomers alone.
Caused minimal cell shrinkage and preserved neurite processes, unlike cells treated with tau oligomers alone.
化学情報
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CAS 番号 531-57-7
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性状 Solid
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分子量 277.78
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分子式 C13H12ClN3S
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Color Brown to dark green
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SMILES
[Cl-].N=1C2=CC=C(N)C=C2[S+]=C3C=C(C=CC13)NC
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別名
Monomethylthionine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 1.96 mg/mL (7.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6000 mL | 17.9999 mL | 35.9997 mL | 89.9993 mL |
| 5 mM | 0.7200 mL | 3.6000 mL | 7.1999 mL | 17.9999 mL |
Azure C 関連分類
HY-W143216 関連分類
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