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製品番号: HY-111837

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BI1071

BI1071 is an orally active Nur77-Bcl-2 apoptotic pathway modulator. BI1071 can bind to Nur77-LBD protein with a K_d of 0.17 μM. BI1071 can activate Nur77 signaling and induce apoptosis by translocating to mitochondria where it interacts with Bcl-2. BI1071 can inhibit tumor growth in SW620 xenograft mice model. BI1071 can be used for research of colon cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₅H₁₉F₃N₂O₃S
分子量:484.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BI1071 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

Nur77/NR4A1

Bcl-2

Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示 :

Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.17 μM Compound: BI1071; 8n	Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
HCT-116	IC₅₀	0.27 μM Compound: BI1071; 8n	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
MCF-10A	IC₅₀	4.29 μM Compound: BI1071; 8n	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
MDA-MB-231	IC₅₀	0.22 μM Compound: BI1071; 8n	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
NCM460	IC₅₀	6.84 μM Compound: BI1071; 8n	Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]
SW-620	IC₅₀	0.18 μM Compound: BI1071; 8n	Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay	[PMID: 33279290]

化学情報

分子量 484.49
分子式 C₂₅H₁₉F₃N₂O₃S
SMILES

FC(C1=CC=C([C+](C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1)(F)F.CS(=O)([O-])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen X, et al. BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway. Mol Cancer Ther. 2019 May;18(5):886-899. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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BI1071

Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示

Bcl-2 Family アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

BI1071 関連分類

HY-111837 関連分類