Biotin-NAD+
Biotin-NAD+ is a PARylation donor and also a substrate of poly (ADP-ribose) polymerase-1 (PARP1). Under the mediation of PARP1, Biotin-NAD+ undergoes poly (ADP-ribosyl) ation to generate biotinylated poly (ADP-ribose) polymers. Biotin-NAD+ can be used for pull-down assays of PARylated proteins in renal epithelial cells. Biotin-NAD+ is applicable to cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 146385-37-7
- 分子式: C39H57N11O17P2S
- 分子量:1045.95
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Biotin-NAD+ (20 nM; 30 min) acts as the optimal substrate for PARP1-mediated PARylation in this electrochemical detection system, enabling maximum signal generation via avidin-biotin capture of biotinylated PAR polymers and NA-AgNPs[1].
Biotin-NAD+ (20 nM; 30 min) serves as the optimal substrate for PARP1-mediated PARylation in this SPR detection system, enabling maximum capture of biotinylated PAR polymers on the NA-modified gold chip[1].
Biotin-NAD+ (6 μg; 24-48 h) serves as an effective PARylation donor to pulldown and detect PARylated proteins, including PARP-1, in mpkCCDc14 cells, revealing a dDAVP time-dependent induction of these modified targets[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 146385-37-7
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分子量 1045.95
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分子式 C39H57N11O17P2S
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SMILES
O=C(NCCCCCCNC(CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1)=O)CNC3=C4C(N(C=N4)[C@@H]5O[C@H](COP(O)(OP(OC[C@@H]6[C@@H](O)[C@@H](O)[C@H]([N+]7=CC=CC(C(N)=O)=C7)O6)([O-])=O)=O)[C@@H](O)[C@H]5O)=NC=N3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Yang S, et al. Electrochemical detection of poly(ADP-ribose) polymerase-1 with silver nanoparticles as signal labels by integrating the advantages of homogeneous reaction with surface-tethered detection. Talanta. 2025;281:126796. [Content Brief]
[2]. Jang HJ, et al. Poly(ADP-ribose) polymerase-1 affects vasopressin-mediated AQP2 expression in collecting duct cells of the kidney. Am J Physiol Renal Physiol. 2024;326(1):F69-F85. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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