BMS-952048
BMS-952048 is a positive allosteric modulator of mGluR5 with an EC50 of 10 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1375751-32-8
- 分子式: C21H13F2N3O2
- 分子量:377.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>3000 nM
Compound: 22; BMS-952048
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Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
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[PMID: 27496211] |
| HEK293 | EC50 |
10 nM
Compound: 22; BMS-952048
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Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
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[PMID: 27496211] |
化学情報
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CAS 番号 1375751-32-8
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分子量 377.34
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分子式 C21H13F2N3O2
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SMILES
O=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BMS-952048 関連分類
HY-123874 関連分類
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