BNS808
Based on 1 Customer Validation
BNS808 is an orally active and selective cannabinoid-1 receptor (CB1R) antagonist (IC50 = 0.8 nM) with notable CB2R selectivity and minimal brain penetration. BNS808 is studied in research on obesity and its associated metabolic complications, such as metabolic dysfunctional-associated steatotic liver disease (MASLD). BNS808 has reduced free drug availability for CNS entry, enhancing safety and minimizing drug-drug interactions through high plasma binding.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.25%
- CAS 番号: 2836313-12-1
- 分子式: C25H20Cl3N3O3S
- 分子量:548.87
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CYP2C9 2.99 μM (IC50) |
CYP2C19 8.33 μM (IC50) |
CYP1A2 18.0 μM (IC50) |
CYP2D6 >50 μM (IC50) |
CB1R 0.8 nM (IC50) |
BNS808 (72 h) displays very low cytotoxicity in HepG2 cells with an IC50 of 16.84 μM[1].
BNS808 demonstrates a hERG IC50 of 5.39 μM suggesting low potential for cardiotoxicity since its IC50 for CB1R is 0.8 nM[1].
BNS808 (0.2 mg/mL, 10 min) exhibits moderate inhibition of CYP3A4, weak-moderate inhibition of CYP2C9 and CYP2C19, and weak inhibition of CYP1A2 and CYP2D6, with IC50 values of 2.99, 8.33, 18.0, and >50 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BNS808 (1 mg/kg, p.o., 24 d) demonstrates limited brain penetrance (around 20 ng/g) after chronic administration in C57Bl/6 mice[1].
BNS808 (1-10 mg/kg, p.o.) shows no CNS-mediated side effects in wide-type male C57Bl/6J mice at low (1 mg/kg) and high (10 mg/kg) doses and no significant changes in locomotor activity[1].
BNS808 (1 mg/kg/day, p.o., 24 days) reduces body weight and improves metabolic profile in diet-induced obese (DIO) C57Bl/6J mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diet-induced obese (DIO) male C57Bl/6J mice [1]
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Dosage:1 mg/kg/day, 24 days
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Administration:Oral gavage (p.o.)
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Result:Reduced body weight attributing to a reduction in total body fat with a significant increase in lean body mass.
Suggested a trend toward substantial effects of the drug on glucose homeostasis and reduced glucose levels in fasting conditions.
Demonstrated efficacy in reversing hepatic steatosis and hepatocellular damage.
Led to a significant reduction in liver triglyceride content and liver enzymes, including ALT, AST, and ALP.
化学情報
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CAS 番号 2836313-12-1
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性状 Solid
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分子量 548.87
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分子式 C25H20Cl3N3O3S
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Color White to off-white
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SMILES
ClC1=CC=C(S(=O)(NC2CCCOC3=C(C4=CC=C(Cl)C=C4)N(C5=C(Cl)C=CC=C5)N=C23)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (182.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8219 mL | 9.1096 mL | 18.2193 mL | 45.5481 mL |
| 5 mM | 0.3644 mL | 1.8219 mL | 3.6439 mL | 9.1096 mL | |
| 10 mM | 0.1822 mL | 0.9110 mL | 1.8219 mL | 4.5548 mL | |
| 15 mM | 0.1215 mL | 0.6073 mL | 1.2146 mL | 3.0365 mL | |
| 20 mM | 0.0911 mL | 0.4555 mL | 0.9110 mL | 2.2774 mL | |
| 25 mM | 0.0729 mL | 0.3644 mL | 0.7288 mL | 1.8219 mL | |
| 30 mM | 0.0607 mL | 0.3037 mL | 0.6073 mL | 1.5183 mL | |
| 40 mM | 0.0455 mL | 0.2277 mL | 0.4555 mL | 1.1387 mL | |
| 50 mM | 0.0364 mL | 0.1822 mL | 0.3644 mL | 0.9110 mL | |
| 60 mM | 0.0304 mL | 0.1518 mL | 0.3037 mL | 0.7591 mL | |
| 80 mM | 0.0228 mL | 0.1139 mL | 0.2277 mL | 0.5694 mL | |
| 100 mM | 0.0182 mL | 0.0911 mL | 0.1822 mL | 0.4555 mL |
BNS808 関連分類
HY-172808 関連分類
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