BRD4-IN-4
Based on 1 Customer Validation
BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 96.0%
- CAS 番号: 304685-40-3
- 分子式: C17H18N2O3S
- 分子量:330.40
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 6.83 μM (BRD4)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
11.67 μM
Compound: 1
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Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 29730189] |
化学情報
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CAS 番号 304685-40-3
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性状 Solid
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分子量 330.40
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分子式 C17H18N2O3S
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Color Brown to reddish brown
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SMILES
O=C1C2=CC=CC3=C(S(=O)(N4CCCC4)=O)C=CC(N1CC)=C32
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (302.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0266 mL | 15.1332 mL | 30.2663 mL | 75.6659 mL |
| 5 mM | 0.6053 mL | 3.0266 mL | 6.0533 mL | 15.1332 mL | |
| 10 mM | 0.3027 mL | 1.5133 mL | 3.0266 mL | 7.5666 mL | |
| 15 mM | 0.2018 mL | 1.0089 mL | 2.0178 mL | 5.0444 mL | |
| 20 mM | 0.1513 mL | 0.7567 mL | 1.5133 mL | 3.7833 mL | |
| 25 mM | 0.1211 mL | 0.6053 mL | 1.2107 mL | 3.0266 mL | |
| 30 mM | 0.1009 mL | 0.5044 mL | 1.0089 mL | 2.5222 mL | |
| 40 mM | 0.0757 mL | 0.3783 mL | 0.7567 mL | 1.8916 mL | |
| 50 mM | 0.0605 mL | 0.3027 mL | 0.6053 mL | 1.5133 mL | |
| 60 mM | 0.0504 mL | 0.2522 mL | 0.5044 mL | 1.2611 mL | |
| 80 mM | 0.0378 mL | 0.1892 mL | 0.3783 mL | 0.9458 mL | |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3027 mL | 0.7567 mL |
BRD4-IN-4 関連分類
HY-153751 関連分類
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