Caspofungin
Based on 10 publication(s) in Google Scholar
Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
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- 純度: 99.50%
- CAS 番号: 162808-62-0
- 分子式: C52H88N10O15
- 分子量:1093.31
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Caspofungin
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Cell Mol Immunol. 2023 Apr;20(4):351-364. [Abstract]
- J Agric Food Chem. 2025 Jul 9;73(27):16787-16803. [Abstract]
- EMBO Rep. 2022 Jun 7;23(6):e53932. [Abstract]
- Bioorg Chem. 2025 Dec:167:109253. [Abstract]
- Front Microbiol. 2024 Jul 30:15:1450557. [Abstract]
- J Fungi (Basel). 2024 May 31;10(6):397. [Abstract]
- Microbiol Spectr. 2025 Mar 31:e0318524. [Abstract]
- Cell Physiol Biochem. 2016 Aug 12;39(3):939-949. [Abstract]
- Research Square Preprint. 2024 Nov 20.
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>100 μg/mL
Compound: Caspofungin
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Cytotoxicity against human HeLa cells after 48 hrs by SRB assay
Cytotoxicity against human HeLa cells after 48 hrs by SRB assay
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[PMID: 26848627] |
| HepG2 | CC50 |
32 μg/L
Compound: CAS
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay
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[PMID: 33335669] |
Caspofungin (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Complement component 5-deficient DBA/2N mice[1]
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Dosage:1, 2, 4 and 8 mg/kg
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Administration:Intraperitoneal injection; daily, for 7 days.
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Result:Reduced the concentration of Candida load in the brain.
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Animal Model:Male C57BL/6 mice[2]
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Dosage:0.41, 1.2, 2.5, 4.1, and 41 μM
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Administration:Intraperitoneal injection; for 5 weeks
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Result:Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
化学情報
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CAS 番号 162808-62-0
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性状 Solid
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分子量 1093.31
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分子式 C52H88N10O15
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Color White to off-white
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SMILES
O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC=C3O)O)=O)([H])[C@H](O)CCN)N(CC[C@@H]4O)[C@]4([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)NCCN)=O
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別名
MK-0991; L-743872
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (10)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Cell Mol Immunol
A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19. [Abstract]2023 Apr;20(4):351-364. PMID: 36864189 -
J Agric Food Chem
Transcription Repressor SsGATA2 Regulates Broad-Spectrum Resistance to Fungicides and Pathogenicity in Sclerotinia sclerotiorum. [Abstract]2025 Jul 9;73(27):16787-16803. PMID: 40558024 -
EMBO Rep
2022 Jun 7;23(6):e53932. PMID: 35403787 -
Bioorg Chem
Glycolysis-mediated energy metabolism mechanisms: Synergistic antifungal activity of (±)-methylagrimonolide against drug-resistant Candida albicans. [Abstract]2025 Dec:167:109253. PMID: 41242040
Caspofungin purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]
Caspofungin (5 mg/kg; i.g.; once daily for 8 d) treatment effectively alleviated the atrophy of thymus and spleen in mice.
Caspofungin purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]
Caspofungin (5 mg/kg; i.g.; once daily for 8 d) treatment enabled C57BL/6 mice infected with C. albicans ATCC14053-FR to maintain their body weight.
Caspofungin purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]
HE-stained and PASM-stained sections of kidneys and lungs after treatment. Caspofungin (5 mg/kg; i.g.; once daily for 8 d) diminished lesion areas, reduced inflammatory cell infiltration, and significantly improved renal tubular damage and alveolar edema.
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Front Microbiol
Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans. [Abstract]2024 Jul 30:15:1450557. PMID: 39139375
Caspofungin purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2024 Jul 30:15:1450557. [Abstract]
Caspofungin (50 μg; 30 ℃; 2 d) showed clear ZOI for wild-type strain SC5314 and two strains bearing ChrR trisomy and tetrasomy.
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J Fungi (Basel)
In Vitro Activitiy of Rezafungin in Comparison with Anidulafungin and Caspofungin against Invasive Fungal Isolates (2017 to 2022) in China. [Abstract]2024 May 31;10(6):397. PMID: 38921383 -
Microbiol Spectr
Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis. [Abstract]2025 Mar 31:e0318524. PMID: 40162832 -
Cell Physiol Biochem
2016 Aug 12;39(3):939-949. PMID: 27513568
Caspofungin purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016 Aug 12;39(3):939-949. [Abstract]
Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).
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純度とドキュメンテーション
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参考文献
[1]. Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7. [Content Brief]
[2]. Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803. [Content Brief]
Calculators
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Caspofungin 関連分類
HY-17006A 関連分類
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