CBiPES
Based on 1 Customer Validation
CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases, such as Parkinson's disease (PD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.74%
- CAS 番号: 353235-01-5
- 分子式: C21H19N3O2S
- 分子量:377.46
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Neuronal Signaling Compound Library
HY-L013
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Neurotransmitter Receptor Compound Library
HY-L062
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Allosteric Modulators (AMs) Compound Library
HY-L170
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
生物活性
EC50: 92.8 nM (mGlu2 receptor)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | CC50 |
13.4 μM
Compound: CBIPES
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Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
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10.21203/rs.3.rs-23951/v1 |
| Caco-2 | IC50 |
17.05 μM
Compound: CBIPES
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Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
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10.21203/rs.3.rs-23951/v1 |
CBiPES (0.1-10 mg/kg) reduces global dyskinesia and diminishes global psychosis-like behaviours (PLBs) in the MPTP (HY-15608)-lesioned marmoset[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice were given a subcutaneous injection of PCP (7.5 mg/kg)[1]
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Dosage:100 mg/kg
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Administration:i.p.; once
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Result:Attenuated a stress-induced hyperthermia and PCP-induced hyperlocomotor activity.
化学情報
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CAS 番号 353235-01-5
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性状 Solid
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分子量 377.46
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分子式 C21H19N3O2S
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Color White to off-white
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SMILES
CCS(N(C1=CC(C2=CC=C(C#N)C=C2)=CC=C1)CC3=CN=CC=C3)(=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (264.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Johnson MP, et al. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology (Berl). 2005 Apr;179(1):271-83. [Content Brief]
[2]. Frouni I, et al. Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. J Neural Transm (Vienna). 2021 Jan;128(1):73-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6493 mL | 13.2464 mL | 26.4929 mL | 66.2322 mL |
| 5 mM | 0.5299 mL | 2.6493 mL | 5.2986 mL | 13.2464 mL | |
| 10 mM | 0.2649 mL | 1.3246 mL | 2.6493 mL | 6.6232 mL | |
| 15 mM | 0.1766 mL | 0.8831 mL | 1.7662 mL | 4.4155 mL | |
| 20 mM | 0.1325 mL | 0.6623 mL | 1.3246 mL | 3.3116 mL | |
| 25 mM | 0.1060 mL | 0.5299 mL | 1.0597 mL | 2.6493 mL | |
| 30 mM | 0.0883 mL | 0.4415 mL | 0.8831 mL | 2.2077 mL | |
| 40 mM | 0.0662 mL | 0.3312 mL | 0.6623 mL | 1.6558 mL | |
| 50 mM | 0.0530 mL | 0.2649 mL | 0.5299 mL | 1.3246 mL | |
| 60 mM | 0.0442 mL | 0.2208 mL | 0.4415 mL | 1.1039 mL | |
| 80 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8279 mL | |
| 100 mM | 0.0265 mL | 0.1325 mL | 0.2649 mL | 0.6623 mL |
CBiPES 関連分類
HY-107505A 関連分類
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