Cefquinome
Based on 1 Customer Validation
Cefquinome is a broad-spectrum cephem antibiotic that has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococci, Streptococci, Pseudomonas, and Enterobacteriaceae.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 84957-30-2
- 分子式: C23H24N6O5S2
- 分子量:528.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Cefquinome binds to penicillin-binding proteins (PBPs), thereby inhibiting the synthesis of bacterial cell walls[3].
Cefquinome inhibits methicillin susceptible S. aureus, Streptococcus spp., Enterococci, E. coli, Salmonella spp., Klebsiella spp., S. marcescens, Enterobacter spp., Citrobacter spp., P. mirabilis, Indole-positive Proteus spp., P. aeruginosa with MICs of 0.006-6.25 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:K. pneumoniae-infected rats models[2]
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Dosage:12.5 mg/kg
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Administration:tail vein injection, single dose
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Result:Reduced lung inflammatory cell infiltration and lung tissue damage.
Inhibited the expression of inflammatory factors TNF-α, IL-1β and IL-8, promoted the expression of anti-inflammatory factors IL-4, IL-10 and IL-13.
化学情報
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CAS 番号 84957-30-2
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分子量 528.60
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分子式 C23H24N6O5S2
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SMILES
O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@@]3([H])SCC(C[N+]4=C5CCCCC5=CC=C4)=C(C([O-])=O)N13
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Chin NX, et al. In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics. Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):331-7. [Content Brief]
[2]. Qu S, et al., Cefquinome-loaded microsphere formulations against Klebsiella pneumonia infection during experimental infections. Drug Deliv. 2018 Nov;25(1):909-915. [Content Brief]
[3]. Limbert M, et al., Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1991 Jan;35(1):14-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cefquinome 関連分類
HY-N6665A 関連分類
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