Cephaloridine
Cephaloridine is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 50-59-9
- 分子式: C19H17N3O4S2
- 分子量:415.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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β-lactam |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
1250 μM
Compound: Cephaloridine
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TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells
TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells
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[PMID: 10929807] |
| HeLa | IC50 |
230 μM
Compound: Cephaloridine
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TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM) in OCTN2-expressing HeLa cells
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM) in OCTN2-expressing HeLa cells
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[PMID: 10636865] |
Cephaloridine can inhibit Staphylococcus aureus penicillin-sensitive strains, penicillin-resistant strains, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium diphtheriae, Clostridium septicum, and so on, with MICs of 0.05-1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits and monkeys[2]
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Dosage:50, 100, 200 and 500 mg/kg
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Administration:i.m.
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Result:Resulted in marked alteration in renal function and necrosis of proximal tubules at 200 and 500 mg/kg.
Did not appear to cause renal injury at 50 and 100 mg/kg.
化学情報
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CAS 番号 50-59-9
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分子量 415.49
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分子式 C19H17N3O4S2
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SMILES
O=C(C(N12)=C(C[N+]3=CC=CC=C3)CS[C@]2([H])[C@H](NC(CC4=CC=CS4)=O)C1=O)[O-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. P. W. Muggleton, et al. Laboratory Evaluation of a New Antibiotic-Cephaloridine (Ceporin). Br Med J. 1964 Nov 14;2(5419):1234-7. [Content Brief]
[2]. Perkins RL, et al. Cephaloridine and cephalothin: comparative studies of potential nephrotoxicity. J Lab Clin Med. 1968 Jan;71(1):75-84. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cephaloridine 関連分類
HY-B2072 関連分類
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