Concanamycin B
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM.
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- CAS 番号: 81552-33-2
- 分子式: C44H71NO14
- 分子量:838.03
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
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Macrolide |
Concanamycin B (5-25 nM, 1h) inhibits the accumulation of lipid droplets and cholesterol esters in macrophages J774 induced by oxidized low-density lipoprotein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 81552-33-2
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分子量 838.03
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分子式 C44H71NO14
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SMILES
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O
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別名
MCH 210
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Structure Classification
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Initial Source
Streptomyces sp
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Yilla M, et al. Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993 Sep 5;268(25):19092-100. PMID: 8395529. [Content Brief]
[2]. Woo JT, et al. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur J Biochem. 1992 Jul 1;207(1):383-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Concanamycin B 関連分類
HY-125707 関連分類
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