Concanamycin B
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 81552-33-2
- 分子式: C44H71NO14
- 分子量:838.03
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-B0003S
Gemcitabine-13C,15N2 hydrochlorideStable Isotope -
HY-124081
N-Oleoyl-L-serineAntiosteoporotic Agent -
HY-17021
EsomeprazoleH+, K+-ATPase Inhibitor -
HY-117887
FidrisertibALK2 Inhibitor -
HY-17023
Esomeprazole sodiumProton Pump Inhibitor -
HY-W003467
Rabeprazole SulfideDrug Metabolite -
HY-B0656A
Rabeprazole sodiumPump Inhibitor -
HY-17021R
Esomeprazole (Standard)H+, K+-ATPase Inhibitor -
HY-131447
KY19382CXXC5-DVL Inhibitor -
HY-126857
5-HydroxyomeprazoleDrug Metabolite -
HY-W003467R
Rabeprazole Sulfide (Standard)Proton Pump Inhibitor -
HY-B0656AR
Rabeprazole sodium (Standard)Pump Inhibitor
Antibiotic アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
|
Macrolide |
体外実験
Concanamycin B (5-25 nM, 1h) inhibits the accumulation of lipid droplets and cholesterol esters in macrophages J774 induced by oxidized low-density lipoprotein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
-
CAS 番号 81552-33-2
-
分子量 838.03
-
分子式 C44H71NO14
-
SMILES
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O
-
別名
MCH 210
-
Structure Classification
-
Initial Source
Streptomyces sp
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
[1]. Yilla M, et al. Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993 Sep 5;268(25):19092-100. PMID: 8395529. [Content Brief]
[2]. Woo JT, et al. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur J Biochem. 1992 Jul 1;207(1):383-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Concanamycin B 関連分類
HY-125707 関連分類
Powered by Bioz