DCG-IV
Based on 1 Customer Validation
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.9%
- CAS 番号: 147782-19-2
- 分子式: C7H9NO6
- 分子量:203.15
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mGluR2R 0.35 μM (EC50) |
mGluR3R 0.09 μM (EC50) |
mGluR1R 389 μM (IC50) |
mGluR5 630 μM (IC50) |
mGluR4R 22.5 μM (IC50) |
mGluR6 39.6 μM (IC50) |
mGluR7 40.1 μM (IC50) |
mGluR8 32 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | EC50 |
45 nM
Compound: DCG-IV
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Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
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[PMID: 20218620] |
| HEK293 | IC50 |
389 μM
Compound: 19
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Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.
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[PMID: 10229625] |
DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
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Dosage:10, 5, or 1 mg/kg
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Administration:I.p.
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Result:Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
化学情報
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CAS 番号 147782-19-2
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性状 Solid
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分子量 203.15
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分子式 C7H9NO6
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Color White to off-white
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SMILES
O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : ≥ 20 mg/mL (98.45 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. [Content Brief]
[2]. Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [Content Brief]
[3]. Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752(1-2):327-30. [Content Brief]
[4]. Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9225 mL | 24.6124 mL | 49.2247 mL | 123.0618 mL |
| 5 mM | 0.9845 mL | 4.9225 mL | 9.8449 mL | 24.6124 mL | |
| 10 mM | 0.4922 mL | 2.4612 mL | 4.9225 mL | 12.3062 mL | |
| 15 mM | 0.3282 mL | 1.6408 mL | 3.2816 mL | 8.2041 mL | |
| 20 mM | 0.2461 mL | 1.2306 mL | 2.4612 mL | 6.1531 mL | |
| 25 mM | 0.1969 mL | 0.9845 mL | 1.9690 mL | 4.9225 mL | |
| 30 mM | 0.1641 mL | 0.8204 mL | 1.6408 mL | 4.1021 mL | |
| 40 mM | 0.1231 mL | 0.6153 mL | 1.2306 mL | 3.0765 mL | |
| 50 mM | 0.0984 mL | 0.4922 mL | 0.9845 mL | 2.4612 mL | |
| 60 mM | 0.0820 mL | 0.4102 mL | 0.8204 mL | 2.0510 mL | |
| 80 mM | 0.0615 mL | 0.3077 mL | 0.6153 mL | 1.5383 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DCG-IV 関連分類
HY-101335 関連分類
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