Dovramilast
Based on 1 Customer Validation
Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (HY-B0329)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.66%
- CAS 番号: 340019-69-4
- 分子式: C24H28N2O6S
- 分子量:472.55
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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PDE4 |
Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice[2].
| Sampling time(h) | Concentration(ng/ml) | ||||
| CC-11050 only | CC-11050+INH | ||||
| 1 | 1,331.6±136.97 | 905.35±594.23 | |||
| 2 | 1,409.47±140.85 | 1,309.39±214.08 | |||
| 5 | 948.85±128.7 | 1,609.18±167.2 | |||
| 8 | 820.6±265.98 | 1,271.73±249.18 | |||
| 24 | 1.27±1.1 | 4.96±1.85 | |||
| Tmax(h) | 2.0 | 5.0 | |||
| Cmax(ng/ml) | 1,410 | 1,610 | |||
| AUClast(ng × h/ml) | 10,200 | 13,900 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6D2F1 mice[2]
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Dosage:5, 25, or 50 mg/kg
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Administration:oral, 5, 25, or 50 mg/kg, single
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Result:Reduced PDE4 expression in mtb-infected mouse lungs.
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Animal Model:B6D2F1 mice[2]
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Dosage:5, 25, or 50 mg/kg
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Administration:oral gavage, 5, 25, or 50 mg/kg, single
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Result:Improved antibiotic-mediated bacterial killing and reduced lung pathology.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 340019-69-4
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性状 Solid
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分子量 472.55
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分子式 C24H28N2O6S
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Color White to off-white
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SMILES
O=C(C1CC1)NC2=CC=CC(CN3[C@@H](C4=CC=C(OC)C(OCC)=C4)CS(=O)(C)=O)=C2C3=O
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別名
CC-11050
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 25 mg/mL (52.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1162 mL | 10.5809 mL | 21.1618 mL | 52.9045 mL |
| 5 mM | 0.4232 mL | 2.1162 mL | 4.2324 mL | 10.5809 mL | |
| 10 mM | 0.2116 mL | 1.0581 mL | 2.1162 mL | 5.2904 mL | |
| 15 mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 3.5270 mL | |
| 20 mM | 0.1058 mL | 0.5290 mL | 1.0581 mL | 2.6452 mL | |
| 25 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1162 mL | |
| 30 mM | 0.0705 mL | 0.3527 mL | 0.7054 mL | 1.7635 mL | |
| 40 mM | 0.0529 mL | 0.2645 mL | 0.5290 mL | 1.3226 mL | |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0581 mL |
Dovramilast 関連分類
HY-147263 関連分類
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