Emilumenib
Based on 1 Customer Validation
Emilumenib (Menin-MLL inhibitor 26) is an orally active Menin-MLL inhibitor. Emilumenib also is an active reference. Emilumenib can inhibits cell growth. Emilumenib can be used for the research of leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.22%
- CAS 番号: 2440018-29-9
- 分子式: C27H29F3N6O3S
- 分子量:574.62
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Emilumenib (0-10 μM, 7 days) inhibits the menin-MLL1 interaction, exhibits cytotoxicity in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells, that inhibits the cell growth of MLL or NPM1 mutated MV4-11, MOLM-13, OCI-AML3 and KOPN-8 with GI50s of 2.5, 6.2, 10 and 28.5 nM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MA9
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Concentration:1.5-41 nM
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Incubation Time:4 days
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Result:Inhibited the expression of Meis1, Hoxa9, Mef2c and Pbx3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MOLM-13 xenograft mouse model[2]
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Dosage:25-200 mg/kg
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Administration:po for 17 days
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Result:Reduced the CD45 positive cells, prolonged the survival time.
化学情報
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CAS 番号 2440018-29-9
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性状 Solid
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分子量 574.62
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分子式 C27H29F3N6O3S
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Color White to off-white
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SMILES
CN([C@H]1C[C@H](C[C@H]1O)NCC2=CC=C(C3=CC(OC)=C(N=N3)OC)C=C2)C4=C5C(SC(CC(F)(F)F)=C5)=NC=N4
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別名
DS-1594a; Menin-MLL inhibitor 26
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 41.67 mg/mL (72.52 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7403 mL | 8.7014 mL | 17.4028 mL | 43.5070 mL |
| 5 mM | 0.3481 mL | 1.7403 mL | 3.4806 mL | 8.7014 mL | |
| 10 mM | 0.1740 mL | 0.8701 mL | 1.7403 mL | 4.3507 mL | |
| 15 mM | 0.1160 mL | 0.5801 mL | 1.1602 mL | 2.9005 mL | |
| 20 mM | 0.0870 mL | 0.4351 mL | 0.8701 mL | 2.1754 mL | |
| 25 mM | 0.0696 mL | 0.3481 mL | 0.6961 mL | 1.7403 mL | |
| 30 mM | 0.0580 mL | 0.2900 mL | 0.5801 mL | 1.4502 mL | |
| 40 mM | 0.0435 mL | 0.2175 mL | 0.4351 mL | 1.0877 mL | |
| 50 mM | 0.0348 mL | 0.1740 mL | 0.3481 mL | 0.8701 mL | |
| 60 mM | 0.0290 mL | 0.1450 mL | 0.2900 mL | 0.7251 mL |
Emilumenib 関連分類
HY-148676 関連分類
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