Enciprazine
Enciprazine is an orally active non-benzodiazepine anxiolytic. Enciprazine acts as an agonist of 5-HT1A receptor (5-HT1AR) and an antagonist of α1-adrenergic receptor (α1-adrenergic receptor) . Enciprazine induces drug-related electroencephalogram changes by reducing the average power of δ waves and θ waves, and increasing the average power of α waves and fast β waves. Enciprazine exhibits anti-aggressive activity, with only weak sedative and ataxic effects. Enciprazine regulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis. Enciprazine can be used in research related to anxiety disorders, generalized anxiety syndrome and psychosis.
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- CAS 番号: 68576-86-3
- 分子式: C23H32N2O6
- 分子量:432.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-HT1A Receptor |
化学情報
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CAS 番号 68576-86-3
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分子量 432.51
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分子式 C23H32N2O6
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SMILES
OC(COC1=CC(OC)=C(OC)C(OC)=C1)CN2CCN(C3=CC=CC=C3OC)CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Engel J, et al. Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. J Med Chem. 1990;33(11):2976-2981. [Content Brief]
[2]. Nickel B, et al. Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology. 1989;28(8):799-803. [Content Brief]
[3]. Matheson GK, et al. Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat. Pharmacology. 1997;55(2):59-65. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Enciprazine 関連分類
HY-19682 関連分類
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