F-14512
Based on 1 Customer Validation
F-14512 is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 can be used to study breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.04%
- CAS 番号: 866874-63-7
- 分子式: C33H47N5O8
- 分子量:641.75
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Clinical Compound Library
HY-L026
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HY-L035
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Lung Cancer Compound Library
HY-L075
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Highly Selective Inhibitors Library
HY-L158
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HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
F-14512 (0.001-100 μM) enters the cell through the polyamine transport system, in CHO cells with normal PTS, the IC50 is 0.12 μM, while in CHO-MG cells with defective PTS, the IC50 is 8.7 μM[1].
F-14512 (72 h) demonstrates high potency in multiple human cell lines (median IC50 = 0.18 μM) and is particularly effective against cell lines such as MX-1, LOX-IMV1, and HL-60[1].
F-14512 (1-100 μM, 1-24 h) induces DNA damage in A549 cells and exhibited stronger cytotoxicity in xrs6 cells with defective DNA repair[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MX-1 human breast cancer xenograft model established in homozygous female athymic nude mice[1]
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Dosage:0.16, 0.32, 0.63, 1.25 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 2 weeks
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Result:Led to tumor regression dose-dependently.
化学情報
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CAS 番号 866874-63-7
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性状 Solid
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分子量 641.75
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分子式 C33H47N5O8
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Color White to off-white
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SMILES
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](NC(CNCCCNCCCCNCCCN)=O)[C@@]2([H])CO1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 125 mg/mL (194.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5582 mL | 7.7912 mL | 15.5824 mL | 38.9560 mL |
| 5 mM | 0.3116 mL | 1.5582 mL | 3.1165 mL | 7.7912 mL | |
| 10 mM | 0.1558 mL | 0.7791 mL | 1.5582 mL | 3.8956 mL | |
| 15 mM | 0.1039 mL | 0.5194 mL | 1.0388 mL | 2.5971 mL | |
| 20 mM | 0.0779 mL | 0.3896 mL | 0.7791 mL | 1.9478 mL | |
| 25 mM | 0.0623 mL | 0.3116 mL | 0.6233 mL | 1.5582 mL | |
| 30 mM | 0.0519 mL | 0.2597 mL | 0.5194 mL | 1.2985 mL | |
| 40 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9739 mL | |
| 50 mM | 0.0312 mL | 0.1558 mL | 0.3116 mL | 0.7791 mL | |
| 60 mM | 0.0260 mL | 0.1299 mL | 0.2597 mL | 0.6493 mL | |
| 80 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4869 mL | |
| 100 mM | 0.0156 mL | 0.0779 mL | 0.1558 mL | 0.3896 mL |
F-14512 関連分類
HY-106031 関連分類
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