製品番号: HY-130247A

Flonoltinib TFA

(別名: JAK2/FLT3-IN-1 TFA)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with IC₅₀ values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib TFA has anti-cancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.04%
CAS 番号: 2928093-29-0
分子式: C₂₇H₃₅F₄N₇O₃
分子量:581.61

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Flonoltinib TFA 構造式

CAS 番号: 2928093-29-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

JAK1

26 nM (IC₅₀)

JAK2

0.7 nM (IC₅₀)

JAK3

39 nM (IC₅₀)

FLT3

4 nM (IC₅₀)

JAK アイソフォーム固有の製品をすべて表示 :

体外実験

Flonoltinib (0.008-1 μM; for 2 hours) TFA down-regulates p-FLT3 in a dose-dependent manner^[1].
Flonoltinib (5-100 nM; for 2 hours) TFA has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells^[1].
Flonoltinib (5-100 nM; for 2 hours) TFA strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MV4-11 and SET-2 cells
Concentration:

0.008, 0.04, 0.2, 1 μM
Incubation Time:

For 2 hours
Result:

Down-regulated p-FLT3 in a dose-dependent manner from 0.008 to 1 μM.

Apoptosis Analysis^[1]

Cell Line:

MV4-11 cells
Concentration:

5, 10, 50, 100 nM
Incubation Time:

For 2 hours
Result:

Had a dose-dependent effect on the induction of apoptosis in the MV4-11 cells.

Cell Cycle Analysis^[1]

Cell Line:

MV4-11 cells
Concentration:

5, 10, 50, 100 nM
Incubation Time:

For 2 hours
Result:

Induced cell cycle arrest with a G1/G0 percentage of 85% at 100 nM.

体内実験

Flonoltinib (30 and 60 mg/kg/day; p.o.; for 14 days) TFA exhibits significant antitumor effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD/SCID mouse models^[1]
Dosage:

30 and 60 mg/kg
Administration:

Oral administration; daily; for 14 days
Result:

Exhibited significant antitumor effects.
The tumor growth inhibitory rates (TGI) were respective 58% and 93% in the MV4-11-bearing mice model.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 2928093-29-0
性状 Solid
分子量 581.61
分子式 C₂₇H₃₅F₄N₇O₃
Color Yellow to orange
SMILES

OCCN(C1CCN(C2=CC=C(NC3=NC=C(C)C(C4=CN(C(C)C)N=C4)=N3)C=C2F)CC1)C.O=C(O)C(F)(F)F
別名

JAK2/FLT3-IN-1 TFA
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

J Immunol

Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells. [Abstract]

2022 Oct 1;209(7):1401-1413. PMID: 36038289

溶剤 & 溶解度

体外:

H₂O : 33.33 mg/mL (57.31 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7194 mL

8.5968 mL

17.1937 mL

5 mM

0.3439 mL

1.7194 mL

3.4387 mL

10 mM

0.1719 mL

0.8597 mL

1.7194 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.7194 mL	8.5968 mL	17.1937 mL	42.9841 mL
	5 mM	0.3439 mL	1.7194 mL	3.4387 mL	8.5968 mL
	10 mM	0.1719 mL	0.8597 mL	1.7194 mL	4.2984 mL
	15 mM	0.1146 mL	0.5731 mL	1.1462 mL	2.8656 mL
	20 mM	0.0860 mL	0.4298 mL	0.8597 mL	2.1492 mL
	25 mM	0.0688 mL	0.3439 mL	0.6877 mL	1.7194 mL
	30 mM	0.0573 mL	0.2866 mL	0.5731 mL	1.4328 mL
	40 mM	0.0430 mL	0.2149 mL	0.4298 mL	1.0746 mL
	50 mM	0.0344 mL	0.1719 mL	0.3439 mL	0.8597 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Flonoltinib TFA

1 Cited Publications

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Flonoltinib TFA

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MedChemExpress（MCE）の使用を引用している文献 Flonoltinib TFA

JAK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Flonoltinib TFA 関連分類

HY-130247A 関連分類