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MED28 - mediator complex subunit 28 Gene

Also Known as EG1; magicin; 1500003D12Rik

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 80306

About MED28

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,614,641-17,634,105 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in ovary (RPKM 18.1), placenta (RPKM 17.9) and 25 other tissues.

Summary

Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and stem cell population maintenance. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MED28 Products (1)

mRNA	Protein	Name
NM_025205.5	NP_079481.2	mediator of RNA polymerase II transcription subunit 28

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	10656681	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED28 Protein Structure

Med28

0
100
178 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 28	endothelial-derived gene 1

MED28 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240	Anti Bait CoIP	15467741
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240-1	Pull Down	15467741
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240-1	Anti Tag CoIP	15467741
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H Prey Pooling	25416956
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H Array	25416956
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H	21516116
Intra	MED28	Q9H204	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	MED28	Q9H204	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	LCK	Homo sapiens	P06239	Anti Bait CoIP	16899217
Intra	MED28	Q9H204	LCK	Homo sapiens	P06239	Protein Kinase Assay	16899217
Intra	MED28	Q9H204	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Cross	MED28	Q9H204	Med30	Mus musculus	Q9CQI9	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MAGI3	Homo sapiens	Q5TCQ9	Peptide Array	16964398
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED6	Homo sapiens	O75586	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED6	Homo sapiens	O75586	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Y2H Array	32296183
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	GRB2	Homo sapiens	P62993	Far-WB	16899217
Intra	MED28	Q9H204	FYN	Homo sapiens	P06241	Anti Bait CoIP	16899217
Intra	MED28	Q9H204	FYN	Homo sapiens	P06241	Y2H	16899217
Intra	MED28	Q9H204	YES1	Homo sapiens	P07947	Anti Bait CoIP	16964398
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Pull Down	16899217
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Anti Bait CoIP	16964398
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Peptide Array	16964398
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Cross	MED28	Q9H204	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Med23	Intellectual Disability, Autosomal Recessive 18 Autosomal Recessive Nonsyndromic Intellectual Disability-18
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Neutropenia, Severe Congenital, X-Linked	X-Linked Severe Congenital Neutropenia XLN SCNX Severe Congenital Neutropenia X-Linked Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS08299	MED28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	MED28	VGNC	VGNC:107347
Rattus norvegicus	MED28	RGD	RGD:1305875
Canis familiaris	MED28	VGNC	VGNC:43135
Macaca mulatta	MED28	VGNC	VGNC:74569
Mus musculus	MED28	MGD	MGI:1914249
Bos taurus	MED28	VGNC	VGNC:31364
Others	MED28	NCBI