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Itepekimab

(別名: REGN-3500; SAR-440340)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • 純度: 99.496%
  • CAS 番号: 2226742-52-3
  • 分子量:144.64 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Itepekimab
  • Experimental Validation Results for Itepekimab
  • Experimental Validation Results for Itepekimab
  • Itepekimab Chemical Structure
    Itepekimab 構造式
CAS 番号: 2226742-52-3
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609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized IL-33 Protein, Human (His, HY-P70475) can bind Itepekimab. The EC50 for this effect is 157.7 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 HUVEC cells with Itepekimab (HY-P99673, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Itepekimab Chemical Structure
    1/16
  • Itepekimab
  • Immobilized IL-33 Protein, Human (His, HY-P70475) can bind Itepekimab. The EC50 for this effect is 157.7 ng/mL.
  • Flow cytometric analysis of 1.5×106 HUVEC cells with Itepekimab (HY-P99673, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).