Lerimazoline
Lerimazoline is a selective 5-HT1D receptor agonist with Ki values of 72 and 3480 nM for h5-HT1D and h5-HT1B. Lerimazoline inhibits Forskolin (HY-15371)-stimulated cAMP production and induces contractions in rabbit saphenous vein preparations. Lerimazoline can be used for the research of migraine.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 54765-26-3
- 分子式: C13H18N2
- 分子量:202.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT1D Receptor 72 nM (Ki) |
5-HT1B Receptor 3480 nM (Ki) |
Lerimazoline (Compound 29) (0.1-1 μM; 60 min) binds to human h5-HT1B receptors with a Ki of 3480 nM[1].
Lerimazoline (0.1-1 μM; 60 min) binds to human h5-HT1D receptors with a Ki of 72 nM, displaying 48-fold selectivity for h5-HT1D over h5-HT1B receptors[1].
Lerimazoline (1-10 μM; 30 min) inhibits Forskolin (HY-15371)-stimulated cAMP production in transfected CHO Pro 5 cells[1].
Lerimazoline (10-10000 nM) induces contractions of rabbit saphenous vein with a 95% of the maximal effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 54765-26-3
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分子量 202.30
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分子式 C13H18N2
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SMILES
CC1=C(CC2=NCCN2)C(C)=CC(C)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lerimazoline 関連分類
HY-135079 関連分類
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