LXY3
Based on 1 Customer Validation
LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.33%
- CAS 番号: 1095009-44-1
- 分子式: C32H43N11O15S2
- 分子量:885.88
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
7.4 μM
Compound: 1, LXY3, cdGTyr(3-NO2)GHypNc
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Binding affinity to alpha3beta1 integrin receptor in human MDA-MB-231 cells assessed as inhibition of cell binding to immobilized LXY1 peptide by cell adherence assay
Binding affinity to alpha3beta1 integrin receptor in human MDA-MB-231 cells assessed as inhibition of cell binding to immobilized LXY1 peptide by cell adherence assay
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[PMID: 19835381] |
化学情報
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CAS 番号 1095009-44-1
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性状 Solid
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分子量 885.88
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分子式 C32H43N11O15S2
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Color White to light yellow
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別名
LXY2
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配列
{d-Cys}-{d-Asp}-Gly-{Tyr(3-NO2)}-Gly-{Hyp}-Asn-{d-Cys}-NH2 (disulfide bridge: d-Cys1-d-Cys8)
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シーケンスの短縮
{d-Cys}-{d-Asp}-G-{Tyr(3-NO2)}-G-{Hyp}-N-{d-Cys}-NH2 (disulfide bridge: d-Cys1-d-Cys8)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (112.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Wang Q, et al. Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours. Nat Nanotechnol. 2024 Jan;19(1):95-105. [Content Brief]
[2]. Yao N. Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial method. J Med Chem. 2009 Jan 8;52(1):126-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1288 mL | 5.6441 mL | 11.2882 mL | 28.2205 mL |
| 5 mM | 0.2258 mL | 1.1288 mL | 2.2576 mL | 5.6441 mL | |
| 10 mM | 0.1129 mL | 0.5644 mL | 1.1288 mL | 2.8221 mL | |
| 15 mM | 0.0753 mL | 0.3763 mL | 0.7525 mL | 1.8814 mL | |
| 20 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4110 mL | |
| 25 mM | 0.0452 mL | 0.2258 mL | 0.4515 mL | 1.1288 mL | |
| 30 mM | 0.0376 mL | 0.1881 mL | 0.3763 mL | 0.9407 mL | |
| 40 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL | |
| 50 mM | 0.0226 mL | 0.1129 mL | 0.2258 mL | 0.5644 mL | |
| 60 mM | 0.0188 mL | 0.0941 mL | 0.1881 mL | 0.4703 mL | |
| 80 mM | 0.0141 mL | 0.0706 mL | 0.1411 mL | 0.3528 mL | |
| 100 mM | 0.0113 mL | 0.0564 mL | 0.1129 mL | 0.2822 mL |
LXY3 関連分類
HY-P10934 関連分類
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