mGluR2 modulator 3
mGluR2 modulator 3 (compound 1) is a potent mGluR2 positive allosteric modulator with an EC50 value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1004614-58-7
- 分子式: C21H25N3O
- 分子量:335.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mGluR2 0.87 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
951 nM
Compound: 3
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Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole-induced effect
Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole-induced effect
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[PMID: 21366332] |
| HEK293 | EC50 |
87 nM
Compound: 3
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Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced intracellular calcium release by FLIPR assay
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced intracellular calcium release by FLIPR assay
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[PMID: 21366332] |
化学情報
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CAS 番号 1004614-58-7
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分子量 335.44
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分子式 C21H25N3O
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SMILES
CN1C2=CC=CC=C2N=C1CN3CCC(CC3)C4=CC=CC=C4OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
mGluR2 modulator 3 関連分類
HY-147529 関連分類
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