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United States

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製品番号: HY-171215

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ML901

ML901 is a reaction-hijacking PfTyrRS inhibitor that blocks ATP consumption and translation. ML901 inhibits PfYRS by forming a covalent Tyr-ML901 adduct and blocking tRNA tyrosylation. ML901 inhibits Atg7-mediated GABARAP activation/transthioesterification and E1 ubiquitin-like activating enzyme activity. ML901 can be used for research on P. falciparum malaria.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2226228-02-8
分子式: C₁₁H₁₄F₂N₆O₇S
分子量:412.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

ML901 構造式

CAS 番号: 2226228-02-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]^[3]

PfYRS

Atg7

33 nM (IC₅₀)

UAE

5.39 μM (IC₅₀)

NAE

28 μM (IC₅₀)

GABARAP

Parasite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1650	EC₅₀	10.02 μM Compound: 4	Antiproliferative activity against human H1650 cells assessed as reduction in cell viability after 72 hrs by cell titer glow assay Antiproliferative activity against human H1650 cells assessed as reduction in cell viability after 72 hrs by cell titer glow assay	[PMID: 32912429]

体外実験

Anti-cancerAutophagyLysosomal MetabolismParasitic InfectionProtein/Amino Acid Metabolism

Anti-cancer

ML901 inhibits HepG2 cell growth, with a 72 h IC₅₀ of 4650 nM^[1].

Autophagy

ML901 inhibits human Atg7 (IC₅₀ 0.033 µM), UAE (IC₅₀ 5.39 µM), and NAE (IC₅₀ 28.0 µM), with no inhibitory effect on SAE at ≤100 µM^[1].

Autophagy

Lysosomal Metabolism

ML901 inhibits human Atg7 with IC₅₀ = 33 nM, while showing weaker activity against other E1 enzymes^[2].

Parasitic Infection

ML901 inhibits the asexual blood-stage growth of Plasmodium falciparum 3D7 with a 72 h IC₅₀ of 2.8 nM, and exhibits a 6 h pulse IC₅₀ of 135 nM against Cam3.II^rev trophozoites^[1].

Parasitic Infection

Protein/Amino Acid Metabolism

ML901 inhibits ATP consumption of recombinant PfTyrRS in the presence of cognate tRNA^Tyr, with an IC₅₀ of 13.4 µM^[1].
ML901 (200 nM; 3 h) activates the amino acid starvation/eIF2α phosphorylation pathway in Plasmodium falciparum through an aaRS-related mechanism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Parasitic Infection

ML901 (50 mg/kg; i.p.; single dose) reduces P. falciparum parasitemia to baseline in human RBC-engrafted SCID mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID (engrafted with human RBCs)^[2]
Dosage:

50 mg/kg
Administration:

i.p.; single dose
Result:

A single 50 mg/kg i.p. dose reduced parasitemia to baseline.

化学情報

CAS 番号 2226228-02-8
分子量 412.33
分子式 C₁₁H₁₄F₂N₆O₇S
SMILES

O[C@@H]1[C@H](O)[C@@H](COS(N)(=O)=O)O[C@H]1N2C3=NC=NC(N)=C3C(OC(F)F)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Stanley C, et al. A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. PLoS Pathog. 2024 Dec 9;20(12):e1012429.

[2]. Xie SC, et al. Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science (New York, N.Y.). 2022 Jun 03;376(6597):1074-1079. [Content Brief]

[3]. Xie SC, et al. Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development. Annu Rev Microbiol. 2023 Sep 15;77:111-129. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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ML901

Parasite アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

Cellular Effect

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

ML901

Parasite アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ML901 関連分類

HY-171215 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target