Nemifitide diTFA
Based on 1 Customer Validation
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.24%
- CAS 番号: 204992-09-6
- 分子式: C37H45F7N10O10
- 分子量:922.80
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2]
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Dosage:0.3 mg/kg
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Administration:IP; daily; for 14 days
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Result:Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.
化学情報
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CAS 番号 204992-09-6
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性状 Solid
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分子量 922.80
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分子式 C37H45F7N10O10
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Color White to off-white
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別名
INN 00835 diTFA
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配列
{Fluoro-Phe}-{Hyp}-Arg-Gly-Trp-NH2
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シーケンスの短縮
{Fluoro-Phe}-{Hyp}-RGW-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
H2O : 250 mg/mL (270.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55(2-3):231-5. [Content Brief]
[2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology (Berl). 2004 Sep;175(3):303-9. [Content Brief]
[3]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressivedisorder. Int J Neuropsychopharmacol. 2006 Oct;9(5):517-28. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0837 mL | 5.4183 mL | 10.8366 mL | 27.0915 mL |
| 5 mM | 0.2167 mL | 1.0837 mL | 2.1673 mL | 5.4183 mL | |
| 10 mM | 0.1084 mL | 0.5418 mL | 1.0837 mL | 2.7091 mL | |
| 15 mM | 0.0722 mL | 0.3612 mL | 0.7224 mL | 1.8061 mL | |
| 20 mM | 0.0542 mL | 0.2709 mL | 0.5418 mL | 1.3546 mL | |
| 25 mM | 0.0433 mL | 0.2167 mL | 0.4335 mL | 1.0837 mL | |
| 30 mM | 0.0361 mL | 0.1806 mL | 0.3612 mL | 0.9030 mL | |
| 40 mM | 0.0271 mL | 0.1355 mL | 0.2709 mL | 0.6773 mL | |
| 50 mM | 0.0217 mL | 0.1084 mL | 0.2167 mL | 0.5418 mL | |
| 60 mM | 0.0181 mL | 0.0903 mL | 0.1806 mL | 0.4515 mL | |
| 80 mM | 0.0135 mL | 0.0677 mL | 0.1355 mL | 0.3386 mL | |
| 100 mM | 0.0108 mL | 0.0542 mL | 0.1084 mL | 0.2709 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Nemifitide diTFA 関連分類
HY-105077A 関連分類
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