Plazomicin
Based on 1 publication(s) in Google Scholar
Plazomicin (ACHN 490) is a semi-synthetic aminoglycoside Antibiotic. Plazomicin acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin is not modified by various common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K. Plazomicin exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1154757-24-0
- 分子式: C25H48N6O10
- 分子量:592.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Plazomicin
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生物活性
製品説明
体外実験
Plazomicin exhibits MIC50/90 = 0.25-0.5 μg/mL/0.5-1 μg/mL Against Klebsiella, Escherichia, Enterobacter, Serratia, and Citrobacter species[1].
Plazomicin selectively inhibits MATE2-K and to a lesser extent MATE1, and OCT2, which are important transporters involved with tubular secretion[1].
Plazomicin (18 h) retains antibacterial activity against most aminoglycoside modifying enzyme-expressing E. coli BW25113 and E. coli BW25113 ΔbamB ΔtolC strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1154757-24-0
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分子量 592.68
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分子式 C25H48N6O10
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SMILES
O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O
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別名
ACHN 490
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
[1]. Clark JA, et al. Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance. Ther Adv Infect Dis. 2020;7:2049936120952604. Published 2020 Sep 4. [Content Brief]
[2]. Cox G, et al. Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS Infect Dis. 2018;4(6):980-987. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Plazomicin 関連分類
HY-16955 関連分類
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Keywords
- Plazomicin
- 1154757-24-0
- ACHN 490
- ACHN490
- ACHN-490
- Antibiotic
- Bacterial
- complicated urinary tract infections
- MATE2-K
- nephrotoxicity
- 16S rRNA ribosomal methyltransferases
- acute pyelonephritis
- carbapenem-resistant Enterobacteriaceae
- aminoglycoside acetyltransferase AAC(2')-Ia
- aminoglycoside phosphotransferase APH(2'')-IVa
- ototoxicity
- Escherichia coli
- Inhibitor
- inhibitor
- inhibit