PM54-1
PM54 is an antitumor agent with activity across multiple cancer types. PM54 acts as a transcription and WNT/β-catenin signaling pathway inhibitor. PM54 suppresses oncogenic transcriptional programs, and key malignant pathways, while inducing DNA double-strand breaks, S-phase cell cycle arrest and apoptosis. PM54 enhances innate immune recognition, remodels the tumor microenvironment. PM54 exhibits antitumor activity as monotherapy or in combination in xenograft models. PM54 is applicable to research on various cancers and advanced solid tumors.
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- CAS 番号: 2248127-86-6
- 分子式: C41H43N3O11S
- 分子量:785.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mTOR |
PM54 (50 nM; 6 h) induces a conserved pan-cancer transcriptional repression program targeting cell cycle, chromatin regulation, and DNA repair in 32 diverse cancer cell lines, with primed responders (characterized by strong suppression of MYC, mTOR, cell cycle, and DNA repair pathways, often with intact TP53 function) exhibiting a more robust transcriptomic response than adaptive responders[1].
PM54 (6-18 h) inhibits WNT/β-catenin-driven transcription in gastric cancer cell lines, reducing activity by ~40% at 6 h and >70% at 18 h[2].
PM54 exhibits strong synergy with 5-fluorouracil in HGC-27 and Hs746T diffuse-type gastric cancer cell lines, and with Cisplatin (HY-17394) in HGC-27 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PM54 (1.2 mg/kg; i.v.; once weekly; 16 days) exhibits strong antitumor activity in soft tissue sarcoma xenograft models, with the most significant effect in the STS134 model where it reduces tumor volume to 76% of baseline[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2248127-86-6
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分子量 785.86
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分子式 C41H43N3O11S
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SMILES
CC(C1=C2OCO1)=C(OC(C)=O)C3=C2[C@H](CO4)N([C@@H](O)C5N(C)C6C7=C(C=C(C)C(OC)=C7O)C5)[C@@]6([H])[C@@H]3SC[C@](C8=C9C%10=CC=CC=C%10O8)(N[C@H](CO)C9)C4=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PM54-1 関連分類
HY-183631 関連分類
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