Propiomazine
Based on 1 Customer Validation
Propiomazine is an orally active antihistamine agent. Propiomazine is a potent prolactin (PRL) release stimulant, whose effect depends on the antagonism of the dopaminergic system and can inhibit the secretion of luteinizing hormone (LH). Propiomazine is mainly used for anesthesia assistance, mental disorders and anxiety-induced sedation, and can also be used in research related to insomnia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.91%
- CAS 番号: 362-29-8
- 分子式: C20H24N2OS
- 分子量:340.48
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 362-29-8
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性状 Oil
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分子量 340.48
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分子式 C20H24N2OS
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Color Light yellow to yellow
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SMILES
CCC(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 83.33 mg/mL (244.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42. [Content Brief]
[2]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. [Content Brief]
[4]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9370 mL | 14.6851 mL | 29.3703 mL | 73.4257 mL |
| 5 mM | 0.5874 mL | 2.9370 mL | 5.8741 mL | 14.6851 mL | |
| 10 mM | 0.2937 mL | 1.4685 mL | 2.9370 mL | 7.3426 mL | |
| 15 mM | 0.1958 mL | 0.9790 mL | 1.9580 mL | 4.8950 mL | |
| 20 mM | 0.1469 mL | 0.7343 mL | 1.4685 mL | 3.6713 mL | |
| 25 mM | 0.1175 mL | 0.5874 mL | 1.1748 mL | 2.9370 mL | |
| 30 mM | 0.0979 mL | 0.4895 mL | 0.9790 mL | 2.4475 mL | |
| 40 mM | 0.0734 mL | 0.3671 mL | 0.7343 mL | 1.8356 mL | |
| 50 mM | 0.0587 mL | 0.2937 mL | 0.5874 mL | 1.4685 mL | |
| 60 mM | 0.0490 mL | 0.2448 mL | 0.4895 mL | 1.2238 mL | |
| 80 mM | 0.0367 mL | 0.1836 mL | 0.3671 mL | 0.9178 mL | |
| 100 mM | 0.0294 mL | 0.1469 mL | 0.2937 mL | 0.7343 mL |
Propiomazine 関連分類
HY-U00051 関連分類
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