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製品番号: HY-N1338

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Royleanone

(別名: NSC 122417)

Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 6812-87-9
分子式: C₂₀H₂₈O₃
分子量:316.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Royleanone 構造式

CAS 番号: 6812-87-9

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

mTOR/PI3/AKT^[1]

mTOR アイソフォーム固有の製品をすべて表示 :

Akt アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	30.14 μM Compound: 20	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
BXPC-3	GI₅₀	51.04 μM Compound: 20	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	GI₅₀	36.33 μM Compound: 20	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23865778]
MCF7	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23865778]
MIA PaCa-2	IC₅₀	32.5 μM Compound: 3	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MOLT-3	IC₅₀	13.6 μM Compound: 3	Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay	[PMID: 23865778]
MRC5	GI₅₀	45.7 μM Compound: 20	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PANC-1	GI₅₀	52.55 μM Compound: 20	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	27.07 μM Compound: 20	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
SK-MEL-1	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay	[PMID: 23865778]
U-937	IC₅₀	>30 μM Compound: 3	Cytotoxicity against human U937 cells after 72 hrs by MTT assay Cytotoxicity against human U937 cells after 72 hrs by MTT assay	[PMID: 23865778]

体外実験

Royleanone (0-200 μM; 48 h) inhibits the viability of LNCaP cancer cells in a dose-dependent manner, with an IC₅₀ of 12.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 6812-87-9
分子量 316.43
分子式 C₂₀H₂₈O₃
SMILES

O=C1C(C(C)C)=C(O)C(C2=C1CC[C@@]3([H])C(C)(C)CCC[C@]23C)=O
別名

NSC 122417
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Plants
- Labiatae
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wu X, et al. Royleanone diterpenoid exhibits potent anticancer effects in LNCaP human prostate carcinoma cells by inducing mitochondrial mediated apoptosis, cell cycle arrest, suppression of cell migration and downregulation of mTOR/PI3K/AKT signalling pathway. J BUON. 2018 Jul-Aug;23(4):1055-1060. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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Royleanone

mTOR アイソフォーム固有の製品をすべて表示

Akt アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Royleanone 関連分類

HY-N1338 関連分類