RS-23597
RS-23597 is a 5-HT4R antagonist with a Ki value of 19 nM against guinea pig 5-HT4R. RS-23597 inhibits the relaxation of the esophageal muscularis mucosae in rats. RS-23597 regulates 5-HT4R-Gs protein coupling and triggers the Gs-mediated cAMP signaling pathway. RS-23597 is applicable to the research of neurological diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 172679-58-2
- 分子式: C16H23ClN2O3
- 分子量:326.82
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
5-HT Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
|
5-HT4 Receptor 19 nM (Ki) |
RS-23597 (Compound 98) is a potent and selective 5-HT4 receptor antagonist in the rat esophageal muscularis mucosa, with a pA2 value of 7.8, and it exhibits only weak antagonistic activity against the 5-HT3 receptor[1].
RS-23597 binds to 5-HT4 receptors in guinea pig striatal membranes with an apparent Ki value of 19 nM, and functions as a partial agonist[2].
RS-23597 induces cAMP production in cells expressing human 5-HT4 receptors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 172679-58-2
-
分子量 326.82
-
分子式 C16H23ClN2O3
-
SMILES
O=C(OCCCN1CCCCC1)C=2C=C(Cl)C(N)=CC2OC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RS-23597 関連分類
HY-145457 関連分類
Powered by Bioz