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製品番号: HY-N19133

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Shearinine A

Name: Shearinine A
Brand: MedChemExpress
SKU: HY-N19133
Availability: PreOrder

(別名: (+)-Shearinine A)

Shearinine A ((+)-Shearinine A) is an orally active insecticidal indole alkaloid present in the sclerotioid ascostromata of the endophytic fungi Aspergillus fumigatus GCV-12 and Eupenicillium shearii. Shearinine A inhibits methicillin-resistant Staphylococcus aureus (MRSA). Shearinine A exhibits biological activity against corn earworms and dried fruit beetles. Shearinine A can be used in studies related to bacterial infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 163136-24-1
分子式: C₃₇H₄₅NO₅
分子量:583.77

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Shearinine A 構造式

CAS 番号: 163136-24-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Antibiotic アイソフォーム固有の製品をすべて表示 :

体外実験

Shearinine A (compound 1) (25.0 μg/mL) inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 25.0 μg/mL^[1].
Shearinine A (compound 1) undergoes 15% autoxidation to its dioxoindole analog when stirred in methanol in air at room temperature for 72 hours^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Shearinine A (compound 1) (100 ppm; dietary; continuous feeding) causes an 89% reduction in weight gain of Helicoverpa zea larvae relative to controls^[2].
Shearinine A (100 ppm; dietary; continuous feeding) causes a 69% reduction in feeding rate and a 48% reduction in weight gain of Carpophilus hemipterus larvae relative to controls^[2].
Shearinine A (2 μg/insect; topical; single application) causes an 80% reduction in weight gain of first instar Helicoverpa zea larvae relative to controls^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 163136-24-1
分子量 583.77
分子式 C₃₇H₄₅NO₅
SMILES

O[C@]12C=3[C@]4(O[C@](C(C)(C)O4)(C(=O)C3)[H])CC[C@]1(C)[C@@]5(C)C6=C(C[C@@]5(CC2)[H])C=7C(N6)=CC8=C(C7)C[C@]9(C8=CC(C)(C)OC9(C)C)[H]
別名

(+)-Shearinine A
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Microorganism
Eupenicillium shearii
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Bo H, et al. Indole-Diterpenoids with Anti-MRSA Activity from the Endophytic Fungus Aspergillus fumigatus. Chemistry of Natural Compounds. 2025;61:827-830.

[2]. Belofsky GN, et al. Antiinsectan alkaloids: Shearinines A-C and a new paxilline derivative from the ascostromata of Eupenicillium shearii. Tetrahedron. 1995;51(14):3959-3968.

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