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Tebentafusp

(別名: IMCgp100)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells.

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  • 純度 : 99.90%
  • CAS 番号: 1874157-95-5
  • 分子量:76.16 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tebentafusp
  • Experimental Validation Results for Tebentafusp
  • Experimental Validation Results for Tebentafusp
  • Tebentafusp Chemical Structure
    Tebentafusp 構造式
CAS 番号: 1874157-95-5
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    scFv-TR-Alpha_Beta-2

  • 1/16

    Loaded HLA-A*0201 GP100 Complex Protein, Human (Biotinylated, YLEPGPVTA, HEK293, His-Avi, HY-P77754) on NTA biosensor, can bind Tebentafusp with an affinity constant of 7.761E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tebentafusp (HY-P99339). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Tebentafusp Chemical Structure
    1/16
  • Tebentafusp
  • Loaded HLA-A*0201 GP100 Complex Protein, Human (Biotinylated, YLEPGPVTA, HEK293, His-Avi, HY-P77754) on NTA biosensor, can bind Tebentafusp with an affinity constant of 7.761E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tebentafusp (HY-P99339). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • scFv-TR-Alpha_Beta-2