TFSeB
TFSeB is an orally active neuroprotective agent. TFSeB can reduce Streptozotocin (STZ) (HY-13753) induced MAO-B and AChE activity. TFSeB exerts neuroprotective effects by increasing the expression of BCL-2, BDNF, NRF2, and decreasing the expression of BAX. TFSeB can reduce lipid peroxidation (TBARS) and reactive oxygen species (ROS) levels. TFSeB can reduce neuroinflammation. TFSeB can be used for research on Alzheimer’s disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3017240-62-6
- 分子式: C16H13F3OSe
- 分子量:357.23
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Bcl-2 |
AChE |
Bax |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss mice (25-35 g) received intracerebroventricular injections of Streptozotocin (STZ) (HY-13753) (3 mg/kg)[1]
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Dosage:1 mg/kg or 5 mg/kg
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Administration:Oral gavage (i.g.); once daily for 20 days
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Result:Significantly improved STZ-induced spatial working memory deficits.
Restored short-term and long-term recognition memory in the mice with an Alzheimer’s disease.
Significantly reduced MAO-B activity as a MAO-B modulator.
Significantly reversed AChE activity in the STZ mice.
Improved oxidative stress levels, including a reduction in TBARS, ROS, NOx, and NPSH levels.
Upregulated the levels of BDNF, NRF2 and BCL-2 and downregulated the levels of NF-κB, IL-6, CAT, SOD, GSk3B and BAX.
Did not cause liver, kidney toxicity or metabolic abnormalities.
化学情報
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CAS 番号 3017240-62-6
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分子量 357.23
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分子式 C16H13F3OSe
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SMILES
FC(F)(C1=CC=CC([Se]CC2CC3=C(O2)C=CC=C3)=C1)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TFSeB 関連分類
HY-174419 関連分類
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