Thalidomide-benzo
Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 458151-34-3
- 分子式: C17H12N2O4
- 分子量:308.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cereblon |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
>50 μM
Compound: 1d
|
Cytotoxicity against human DLD1 cells by MTT assay
Cytotoxicity against human DLD1 cells by MTT assay
|
[PMID: 19394719] |
| HL-60 | IC50 |
>50 μM
Compound: 1d
|
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
|
[PMID: 19394719] |
| HT-29 | IC50 |
>50 μM
Compound: 1d
|
Cytotoxicity against human HT-29 cells by MTT assay
Cytotoxicity against human HT-29 cells by MTT assay
|
[PMID: 19394719] |
| HUVEC | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against HUVEC by MTT assay
Cytotoxicity against HUVEC by MTT assay
|
[PMID: 19394719] |
| ST486 | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against human ST486 cells by MTT assay
Cytotoxicity against human ST486 cells by MTT assay
|
[PMID: 19394719] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 458151-34-3
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分子量 308.29
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分子式 C17H12N2O4
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SMILES
O=C1NC(C(CC1)N2C(C3=CC4=C(C=C3C2=O)C=CC=C4)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Thalidomide-benzo 関連分類
HY-139549 関連分類
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