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製品番号: HY-109077

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Tigolaner

(別名: BAY-1272858)

カスタマーレビュー

Based on 1 Customer Validation

Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.37%
CAS 番号: 1621436-41-6
分子式: C₂₁H₁₃ClF₈N₆O
分子量:552.81

保管条件:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Tigolaner 構造式

CAS 番号: 1621436-41-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity^[1].

Parasite アイソフォーム固有の製品をすべて表示 :

体内実験

Tigolaner (intravenous injection/topical administration; 1.5 mg/kg / 14.5 mg/kg; single dose) exerts anti-flea and anti-tick effects in cats^[1].
Plasma Pharmacokinetic Analysis in cats^[1]

Route	Dose rate mg/kg	T_1/2 (h)	T_max (h)	C_max (μg/L)	AUC_last (mg·h/L)	AUC_inf (mg·h/L)	CL_-pred (L/h/kg)	Vz_-pred (L/kg)
topical	14.5	568.2	297.0	1245.1	1516	1566	/	/
i.v.	1.5	515.4	/	/	298	300.1	0.005	4.00

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1621436-41-6
性状 Solid
分子量 552.81
分子式 C₂₁H₁₃ClF₈N₆O
Color White to off-white
SMILES

FC(F)(C(C(C(F)(F)C(F)(F)F)=N1)=C(N2C=C(C(C=C3)=CC(C(NC4(CC4)C#N)=O)=C3Cl)C=N2)N1C)F
別名

BAY-1272858
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (45.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8089 mL

9.0447 mL

18.0894 mL

5 mM

0.3618 mL

1.8089 mL

3.6179 mL

10 mM

0.1809 mL

0.9045 mL

1.8089 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mencke N, et al. Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats. Curr Res Parasitol Vector Borne Dis. 2023 Jun 22;4:100126. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8089 mL	9.0447 mL	18.0894 mL	45.2235 mL
	5 mM	0.3618 mL	1.8089 mL	3.6179 mL	9.0447 mL
	10 mM	0.1809 mL	0.9045 mL	1.8089 mL	4.5223 mL
	15 mM	0.1206 mL	0.6030 mL	1.2060 mL	3.0149 mL
	20 mM	0.0904 mL	0.4522 mL	0.9045 mL	2.2612 mL
	25 mM	0.0724 mL	0.3618 mL	0.7236 mL	1.8089 mL
	30 mM	0.0603 mL	0.3015 mL	0.6030 mL	1.5074 mL
	40 mM	0.0452 mL	0.2261 mL	0.4522 mL	1.1306 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- 体内実験
化学情報
溶剤 & 溶解度
- 体外実験
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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Tigolaner

Covalent Screening Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Antiparasitic Compound library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

GABA Receptor Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Tigolaner

Covalent Screening Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Antiparasitic Compound library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

GABA Receptor Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Tigolaner 関連分類

HY-109077 関連分類